Formalin-fixed, paraffin-embedded human Cervical Carcinoma stained with Cytokeratin 19 Monoclonal Antibody (KRT19/799 + KRT19/800)

Formalin-fixed, paraffin-embedded human Bladder Carcinoma stained with Cytokeratin 19 Monoclonal Antibody (KRT19/799 + KRT19/800)

Formalin-fixed, paraffin-embedded human Ovarian Carcinoma stained with Cytokeratin 19 Monoclonal Antibody (KRT19/799 + KRT19/800)

Formalin-fixed, paraffin-embedded human Endometrial Carcinoma stained with Cytokeratin 19 MAb (KRT19/799 + KRT19/800)

Formalin-fixed, paraffin-embedded human Pancreas stained with Cytokeratin 19 MAb (KRT19/799 + KRT19/800)

Cytokeratin 19 (KRT19) (Pancreatic Stem Cell Marker) [KRT19/799 + KRT19/800]

Name: Cytokeratin 19 (KRT19) (Pancreatic Stem Cell Marker)
SKU: 3880-MSM7
Availability: InStock

Monoclonals Mouse Monoclonals Primary Antibodies

Summary

Recognizes a protein of 40kDa, identified as cytokeratin-19 (CK19), which is expressed in sweat gland, mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, and ectocervical epithelium. Anti-CK19 reacts with a wide variety of epithelial malignancies including adenocarcinomas of the colon, stomach, pancreas, biliary tract, liver, and breast. Perhaps the most useful application is the identification of thyroid carcinoma of the papillary type, although 50%-60% of follicular carcinomas are also labeled. Anti-CK19 is a useful marker for detection of tumor cells in lymph nodes, peripheral blood, bone marrow and breast cancer.

Printable

Product Properties & Targets

Host

Mouse

Species Reactivity

Human, Mouse

Research Areas

Autophagy, Cardiovascular

Isotype

IgG1, IgG2a

Gene Name

KRT19

Mol. Weight of Antigen

40kDa

Immunogen

Recombinant full-length human KRT19 protein

Database Links

Entrez Gene ID

3880

Unigene

654568

SwissProt

P08727

Additional Information

Clone

KRT19/799 + KRT19/800

Human Gene Symbol

KRT19

Chromosome Location

17q21.2

Known Applications & Suggested Dilutions

Immunohistochemistry (Formalin-fixed) (0.1-0.2ug/ml for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Key References

Van Eyken, P., et al. 1991. Immunocytochemistry of cytokeratins in primary human liver tumors. APMIS Suppl. 23: 77-85.
van der Velden, L.A., et al. 1993. Cytokeratin expression in normal and (pre)malignant head and neck epithelia: an overview. Head Neck 15: 133-146.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.