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Cytokeratin 18 (KRT18) Antibody [SPM510]

Additional information

Catalog Number: 3875-MSM2X
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
3875-MSM2X-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
3875-MSM2X-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
3875-MSM2X-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Cytokeratin 18 (KRT18) Antibody

Formalin-fixed, paraffin-embedded human Breast Carcinoma stained with Cytokeratin 18 Mouse Monoclonal Antibody (SPM510).

Cytokeratin 18 (KRT18) Antibody - Image 2

SDS-PAGE Analysis of Purified Cytokeratin 18 Mouse Monoclonal Antibody (SPM510). Confirmation of Integrity and Purity of Antibody

Cytokeratin 18 (KRT18) Antibody - Image 3

Flow Cytometric Analysis of trypsinized paraformaldehyde-fixed HeLa cells using Cytokeratin 18 Mouse Monoclonal Antibody (SPM510) followed by goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).

  • Flow
  • IF
  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Immunofluorescence, Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
SPM510
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cytoplasm, Nucleolus, Nucleus, Perinuclear region
Gene Name
KRT18
Positive Control
Breast cancer., HeLa cells, MCF-7
Immunogen
Human breast cancer PMC 42 cells
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.
Key References
  • Lane EB et. al. Sem Cancer Biol 1:165-179 (1990).2. Lauerova et. al. Hybridoma 7:495-504 (1988).
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
3875
SwissProt
P05783
Chromosome Location
12q13.13
Mol. Weight of Antigen
45kDa
Alternate Names
Keratin, type I cytoskeletal 18, Cell proliferation-inducing gene 46 protein, Cytokeratin-18, Keratin-18, Cell Proliferation-inducing Gene 46 Protein; CK18; CYK18Cytokeratin Endo B; K18; Keratin-18; Kerd; KRT18

Summary

This MAb reacts with a wide variety of simple epithelia. It does not react with stratified squamous epithelia. It reacts with epithelial tumors of the gastrointestinal tract, lung, breast, pancreas, ovary, and thyroid. Cytokeratin 18, which belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. It was reported that tissues from gastrointestinal tract are positive for both cytokeratin 8 and 18 but do not contain cytokeratin 14. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18.

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