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CLEC9A Antibody [1F6]

In Stock
Catalog Number Formulation Size Price
MS232414-RTM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
MS232414-RTM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
MS232414-RTM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-3ug/ml
Western Blot (WB)
2-4ug/ml

Summary

This Mab recognizes mouse DNGR-1, which is also known as CLEC9A, which is a highly specific marker of the CD8a+ and the CD103+ DC subsets, as well as a receptor able to recognize a preformed signal exposed on necrotic cells. In peripheral blood, it is highly restricted on the surface of BDCA31(+) dendritic cells and on a small subset of CD14(+) and CD16(-) monocytes.

Product Properties & Targets

Antibody Type
Host
Rat
Species Reactivity
Isotype / Light Chain
IgG1 /
Cellular Localization
Membrane
Gene Name
Positive Control
Mouse spleen.
Immunogen
RBL-2H3 cells expressing Mouse CLEC9A fused to an HA epitope.
Alternate Names
C-type lectin domain family 9 member A, Dendritic cell natural killer lectin group receptor 1, C type lectin domain family 9, member A; C-type lectin domain family 8 member A; CLEC9A; DNGR1; HEEE9341; PRO34046; UNQ9341; CD370

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
1F6
Chromosome Location
6,63.30 (Mouse)
Mol. Weight of Antigen
27kDa

Functions

  • Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.

Key References

  • Sancho et al. 2008. J Clin Invest 118:2098-110.
  • Sancho et al. 2009. Nature. 458:899-903.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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