SDS-PAGE Analysis Purified CD8b Rat Monoclonal Antibody (H35-17.2). Confirmation of Integrity and Purity of Antibody.

SDS-PAGE Analysis Purified CD8b Rat Monoclonal Antibody (H35-17.2). Confirmation of Integrity and Purity of Antibody.

CD8b, Mouse [H35-17.2]

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Summary

This monoclonal antibody reacts with the Mouse CD8 beta molecule. The CD8 beta chain associates with the CD8 alpha chain to form the CD8 alpha/beta heterodimer expressed on the surface of a majority of thymocytes, and on peripheral cytotoxic alpha beta TCR T cells. This monoclonal antibody identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.

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Product Properties & Targets

Host
Rat
Species Reactivity
Mouse
Isotype
IgG2b
Cellular Localization
Membrane
Gene Name
CD8B
Mol. Weight of Antigen
37kDa
Immunogen
Five day mixed leukocyte culture population, C57BL/6 anti-BALB/c

Database Links

Entrez Gene ID
12526
Unigene
3331
SwissProt
P10300

Additional Information

Clone
H35-17.2
Human Gene Symbol
Cd8b1 (Mouse)
Chromosome Location
6 C1; 6 32.14 cM (Mouse)

Known Applications & Suggested Dilutions

  • Functional Studies (Order Antibody without BSA & Azide)
  • Flow Cytometry (0.5-1ug/million cells in 0.1ml)
  • Immunofluorescence (1-2ug/ml)
  • Optimal dilution for a specific application should be determined.

Key References

  • Fujiura Y, Kawaguchi M, Kondo Y, et al. Development of CD8 alpha alpha+ intestinal intraepithelial T cells in beta 2-microglobulin- and/or TAP1-deficient mice. J Immunol. 1996; 156(8):2710-2715.
  • Bierer BE, Sleckman BP, Ratnofsky SE, Burakoff SJ. The biologic roles of CD2, CD4, and CD8 in T-cell activation. Annu Rev Immunol. 1989; 7:579-599.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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