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CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) Antibody [123A8; same 56C04]

Additional information

Catalog Number: 4684-MSM2
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
4684-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
4684-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
4684-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) Antibody

Formalin-fixed, paraffin-embedded human thyroid stained with CD56 Mouse Monoclonal Antibody (123A8). HIER: Tris/EDTA, pH9.0, 45min. 2 °: HRP-polymer, 30min. DAB, 5min.

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) Antibody - Image 2

Formalin-fixed, paraffin-embedded human pancreas stained with CD56 Mouse Monoclonal Antibody (123A8). HIER: Tris/EDTA, pH9.0, 45min. 2 °: HRP-polymer, 30min. DAB, 5min.

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) Antibody - Image 3

Formalin-fixed, paraffin-embedded human colon stained with CD56 Mouse Monoclonal Antibody (123A8).

CD56 / NCAM1 / NKH1 (Neuronal Cell Marker) Antibody - Image 4

SDS-PAGE Analysis Purified CD56 Mouse Monoclonal Antibody (123A8). Confirmation of Purity and Integrity of Antibody.

CD56 (Neuronal Cell Marker) Antibody in Western Blot (WB)

CD56 (Neuronal Cell Marker) Antibody in Western Blot (WB)

Western blot analysis of Human Brain tissue lysates using CD56 Mouse Monoclonal Antibody (56C04).

CD56 (Neuronal Cell Marker) Antibody in Western Blot (WB)

CD56 (Neuronal Cell Marker) Antibody in Western Blot (WB)

Western blot analysis of Human Brain, Mouse Brain and Rat Brain tissue lysates using CD56 Mouse Monoclonal Antibody (123A8).

  • IF
  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunofluorescence (IF) 1-3ug/ml
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunofluorescence, Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
123A8; same 56C04
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cell membrane, Secreted
Gene Name
NCAM1
Positive Control
Human cerebellum, pancreas or neuroblastoma, Human Brain
Immunogen
Membrane preparation of a small cell lung carcinoma
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Additional information

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Reactivity:

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Additional information

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Reactivity:

, ,

Gene:

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Gene:

Host:

Reactivity:

VIEW ALL ANTIBODIES

Other Information

Functions
  • This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc.
  • (Microbial infection) Acts as a receptor for rabies virus.
  • (Microbial infection) Acts as a receptor for Zika virus.
Key References
  • Gerardy-Schahn R; et. al. Int Journal of Cancer. Supplement, 1994, 8:38-42.
  • Michalides R; et. al. International Journal of Cancer. Supplement, 1994, 8:34-7.
  • K. Moolenaar et al. Cancer Research 50, 1102-1106, 1990
  • Schol DJ; et. al. Int J Cancer. Supplement, 1988, 2:34-40
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
4684
SwissProt
P13591
Chromosome Location
11q23.1
Mol. Weight of Antigen
145 and 125kDa|180
Alternate Names
Neural cell adhesion molecule 1, NCAM, Leu-19, NKH1, MSK39, NCAM120, NCAM140, NCAM180, Neural Cell Adhesion Molecule

Summary

This MAb reacts with an extracellular domain (close to transmembrane) of CD56/NCAM. Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135kDa isoform is the basic molecule, which is glycosylated or sialylated to produce the mature species. Anti-CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed on most neuroectodermally derived tissues and neoplasms (e.g. retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell carcinomas). It is also expressed on some mesodermally derived tumors (rhabdomyosarcoma). Anti-CD56 plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas.

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