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CD50 / ICAM3 [ICO-60]

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Summary

Recognizes the N-glycosylated glycoprotein of 120kDa with intra-chain disulfide bonds, identified as CD50 or ICAM-3. CD50 is the major ligand for LFA-1 (CD11a/CD18) and may have signaling role to increase adhesion. It is expressed on thymocytes and T lymphocytes and is resistant to treatment with phosphatidylinositol (PI) phospholipase C.

Product Properties & Targets

Host
Mouse
Applications
Flow Cytometry, Immunofluorescence
Species Reactivity
Human
Isotype
IgG1
Cellular Localization
Membrane
Light Chain
Kappa
Gene Name
ICAM3
Positive Control
HL-60 or THP-1 cells. Lymph node and tonsil.
Immunogen
Human ICAM3
Alternate Names
Intercellular adhesion molecule 3, CDw50, ICAM-R, ICAMR; Intercellular adhesion molecule 3 (ICAM3)

Database Links

Entrez Gene ID
3385
Unigene
354563
SwissProt
P32942

Additional Information

Clone
ICO-60
Human Gene Symbol
ICAM3
Chromosome Location
19p13.2
Mol. Weight of Antigen
110-160kDa

Functions

  • ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).

Known Applications & Suggested Dilutions

  • Flow Cytometry (1-2ug/million cells)
  • Immunofluorescence (1-2ug/ml)
  • Optimal dilution for a specific application should be determined.

Key References

  • Baryshnikov A. et al., Gemat.Trasf. (Russian) N8, 4-7, (1990)
  • Baryshnikov A, and Tonevitsky A, Monoclonal antibodies in laboratory and clinic. Thesis p212, (1997).
  • Martinova T.et al., In: Problems in medical biotechnology and immunological infections diseases. Vol 11, 182-186 (1996).
  • Leukocyte typing V, Schlossman et al., Oxford Univ. Press, 1546 and 1583 (1993).

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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