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CD45 / LCA (B-Cell Marker) Antibody [PTPRC/1666]

Additional information

Catalog Number: 5788-MSM35
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
5788-MSM35-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
5788-MSM35-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
5788-MSM35-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
CD45 / LCA (B-Cell Marker) Antibody

Western Blot Analysis of human spleen tissue lysates using CD45 Mouse Recombinant Monoclonal Antibody (PTPRC/1666)

CD45 / LCA (B-Cell Marker) Antibody - Image 2

Flow Cytometric Analysis of paraformaldehyde-fixed Jurkat cells using CD45 Mouse Recombinant Monoclonal Antibody (PTPRC/1666) followed by Goat anti-mouse- IgG-CF488 (Blue); Isotype Control (Red).

PTPRC Antibody in SDS-PAGE

PTPRC Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified Receptor-type tyrosine-protein phosphatase C Mouse Monoclonal Antibody (PTPRC/1666). Confirmation of Purity and Integrity of Antibody.

  • Flow
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Western Blot
Species Reactivity
Human
Clone
PTPRC/1666
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cell membrane, Membrane raft
Gene Name
PTPRC
Positive Control
or GA-10 cells. Human tonsil or spleen., Ramos, U-698
Immunogen
Human recombinant full-length CD45 protein
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
  • (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation.
Key References
  • Gatter KC et. al. Lancet, 1985 Jun 8, 1(8441):1302-5.
  • Michie SA et. al. American Journal of Clinical Pathology, 1987, 88(4):457-62.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
5788
SwissProt
P08575
Chromosome Location
1q31.3
Mol. Weight of Antigen
180-220kDa
Alternate Names
Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, T200, B220, CD45R, GP180, Leukocyte common antigen (LCA), Loc, Ly-5, Lyt-4, Protein tyrosine phosphatase receptor type C (PTPRC), Receptor-type tyrosine-protein phosphatase C, T200 glycoprotein

Summary

CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

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