CD44v4/5 (Marker of Tumor Metastasis) Antibody [3D2]

• Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640).

• Thanakit V, et al. J Med Assoc Thai. 2005 Sep;88 Suppl 4:S30-5.
• H. Imam, B. Eriksson K. Oberg. Annals of Oncology 11: 295-300, 2000.

• https://pubmed.ncbi.nlm.nih.gov/2466575/
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• https://pubmed.ncbi.nlm.nih.gov/1281868/
• https://pubmed.ncbi.nlm.nih.gov/1465456/
• https://pubmed.ncbi.nlm.nih.gov/7508842/
• https://pubmed.ncbi.nlm.nih.gov/8352881/
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• https://pubmed.ncbi.nlm.nih.gov/16554811/
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• https://pubmed.ncbi.nlm.nih.gov/7527301/
• https://pubmed.ncbi.nlm.nih.gov/7508992/
• https://pubmed.ncbi.nlm.nih.gov/2007624/
• https://pubmed.ncbi.nlm.nih.gov/8148709/
• https://pubmed.ncbi.nlm.nih.gov/1717145/
• https://pubmed.ncbi.nlm.nih.gov/7528188/
• https://pubmed.ncbi.nlm.nih.gov/12511867/
• https://pubmed.ncbi.nlm.nih.gov/9580567/
• https://pubmed.ncbi.nlm.nih.gov/12032545/
• https://pubmed.ncbi.nlm.nih.gov/12883358/
• https://pubmed.ncbi.nlm.nih.gov/15123640/
• https://pubmed.ncbi.nlm.nih.gov/16335952/
• https://pubmed.ncbi.nlm.nih.gov/17081983/
• https://pubmed.ncbi.nlm.nih.gov/16541107/
• https://pubmed.ncbi.nlm.nih.gov/19367720/
• https://pubmed.ncbi.nlm.nih.gov/18691976/
• https://pubmed.ncbi.nlm.nih.gov/18669648/
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• https://pubmed.ncbi.nlm.nih.gov/19690332/
• https://pubmed.ncbi.nlm.nih.gov/19703720/
• https://pubmed.ncbi.nlm.nih.gov/18757307/
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• https://pubmed.ncbi.nlm.nih.gov/22726066/
• https://pubmed.ncbi.nlm.nih.gov/23589287/
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• https://pubmed.ncbi.nlm.nih.gov/17085435/
• https://pubmed.ncbi.nlm.nih.gov/25195884/
• https://pubmed.ncbi.nlm.nih.gov/8636151/

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960

P16070

11p13

80-95kDa

CD44 antigen, CDw44, Epican, Extracellular matrix receptor III, GP90 lymphocyte homing/adhesion receptor, HUTCH-I, Heparan sulfate proteoglycan, Hermes antigen, Hyaluronate receptor, Phagocytic glycoprotein 1, Phagocytic glycoprotein I, LHR; BA-1; chondroitin sulfate proteoglycan 8 (CSPG8); Epican; Extracellular Matrix Receptor III (ECM III); GP90 Lymphocyte Homing Adhesion Receptor; HCAM; HCELL; hematopoietic cell E- and L-selectin ligand; Heparan Sulfate Proteoglycan; Hermes Antigen; HAS; HUTCH I; Hyaluronate Receptor; Indian blood group; Inlu Related p80 Glycoprotein; Ly 24; MDU2; MDU3; MIC4; MUTCH I; Phagocytic Glycoprotein 1 (PGP-1)