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Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with Calnexin Mouse Monoclonal Antibody (CANX/1541).
Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with Calnexin Mouse Monoclonal Antibody (CANX/1541).
Formalin-fixed, paraffin-embedded human Small Intestinal Carcinoma stained with Calnexin Mouse Monoclonal Antibody (CANX/1541).
Confocal immunofluorescence image of HeLa cells using Calnexin Mouse Monoclonal Antibody (CANX/1541), labeled in Green. Reddot is used to label the nuclei Red.
It recognizes a protein of 90kDa, which is identified as Calnexin. Secretory and transmembrane proteins are synthesized on polysomes and translocate into the endoplasmic reticulum (ER) where they are often modified by the formation of disulfide bonds, amino-linked glycosylation and folding. To help proteins fold properly, the ER contains a pool of molecular chaperones including calnexin. It is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation.
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