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APC / Adenomatous Polyposis Coli / FAP (Tumor Suppressor) Antibody [ALi 12-28]

Additional information

Catalog Number: 324-MSM1
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
324-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
324-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
324-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
APC / Adenomatous Polyposis Coli / FAP (Tumor Suppressor) Antibody

SDS-PAGE Analysis of Purified APC Mouse Monoclonal Antibody (ALi 12-28). Confirmation of Purity and Integrity of Antibody.

  • ELISA
  • Flow
  • IF
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
ELISA, Flow Cytometry, Immunofluorescence, Western Blot
Species Reactivity
Human
Clone
ALi 12-28
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Adherens junction, Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Lamellipodium, Ruffle membrane
Gene Name
APC
Positive Control
Human tonsil, placenta, breast or colon. HCT116 or COLO 320DM cells.
Immunogen
Recombinant fragment of human APC protein (around aa 1-433)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Key References
  • Sunkel, C.E. and Glover, D.M. 1988. J. Cell Sci. 89: 25-38.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
324
SwissProt
P25054
Chromosome Location
5q22.2
Mol. Weight of Antigen
66kDa
Alternate Names
Adenomatous polyposis coli protein, Deleted in polyposis 2.5, Adenomatous Polyposis Coli; CC1; Deleted in polyposis 2.5 (DP2.5); DP2; DP3; FAP; FPC; GS; Protein APC

Summary

The adenomatous polyposis syndromes, familial adenomatous polyposis (FAP) and Gardner's syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein, 2,843 amino acids in length, which is frequently mutated in patients suffering from FAP and GS. APC has been found to be associated with structural components of intracellular junctions. Functions as a tumor suppressor, promoting rapid degradation of CTNNB1 and is a negative regulator of Wnt signaling. Also plays a role in HGF-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

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