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TFAM / TCF6 (Transcription factor A, mitochondrial) / mtTFA Antibody [TFAM/9713]

Additional information

Catalog Number: 7019-MSM1
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
7019-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
7019-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
7019-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Transcription factor A, mitochondrial (TFAM) Antibody in Immunohistochemistry (IHC (P))

Transcription factor A, mitochondrial (TFAM) Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human adrenal gland stained with TFAM Mouse Monoclonal Antibody (TFAM/9713). Inset: PBS instead of primary antibody; secondary only negative control.

TFAM Antibody in Western Blot (WB)

TFAM Antibody in Western Blot (WB)

Western Blot Analysis of HEK293T cell lysate using TFAM Mouse Monoclonal Antibody (TFAM/9713 ).

TFAM Antibody in SDS-PAGE

TFAM Antibody in SDS-PAGE

SDS-PAGE Analysis Purified TFAM Mouse Monoclonal Antibody (TFAM/9713). Confirmation of Purity and Integrity of Antibody.

TFAM Antibody in Western Blot (WB)

TFAM Antibody in Western Blot (WB)

Western blot analysis of brain, liver, pancreas, stomach and spleen tissue lysates from human, mouse, rat and hamster using TFAM Mouse Monoclonal Antibody (TFAM/9713).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
TFAM/9713
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Mitochondrion, Mitochondrion matrix
Gene Name
TFAM
Positive Control
HEK293T, brain, heart, intestine, kidney, liver, lung, pancreas, skeletal muscle, skin or spleen.
Immunogen
Recombinant fragment (around aa1-200) of human TFAM protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind and bend DNA. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA. target DNA. Interacts with TFB1M and TFB2M.
Key References
  • He B, Gao R, Lv S, et al. Cancer cell employs a microenvironmental neural signal trans-activating nucleus-mitochondria coordination to acquire stemness. Signal Transduct Target Ther. 2023;8(1):275. Published 2023 Jul 19. doi:10.1038/s41392-023-01487-4
  • Huang Q, Wu D, Zhao J, et al. TFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis. EMBO J. 2022;41(11):e110324. doi:10.15252/embj.2021110324
  • Hu M, Zhou M, Bao X, et al. ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation. J Clin Invest. 2021;131(3):e139333. doi:10.1172/JCI139333
  • Ruan X, Cao M, Yan W, et al. Cancer-cell-secreted extracellular vesicles target p53 to impair mitochondrial function in muscle. EMBO Rep. 2023;24(9):e56464. doi:10.15252/embr.202256464
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
7019
SwissProt
Q00059
Chromosome Location
10q21.1
Mol. Weight of Antigen
25kDa
Alternate Names
transcription factor A, mitochondrial, anscription factor 6-like 1 antibody; Mitochondrial transcription factor 1 antibody; mitochondrial transcription factor A antibody; MtTF1 antibody; mtTFA antibody; TCF 6 antibody; TCF-6 antibody; TCF6 antibody; TCF6L1 antibody; TCF6L2 antibody; TCF6L3 antibody; TFAM antibody; TFAM_HUMAN antibody; Transcription factor 6 antibody; Transcription factor 6 like 2 (mitochondrial transcription factor) antibody; Transcription factor 6 like 2 antibody; Transcription factor 6-like 2 antibody; transcription factor 6-like 3 antibody; Transcription factor A, mitochondrial antibody; Transcription factor A, mitochondrial antibody; Transcription factor A, mitochondrial precursor antibody, TCF6; MTTF1; MTTFA; TCF6L1; TCF6L2; TCF6L3; MTDPS15

Summary

mtTFA (mitochondrial transcription factor A), also known as mtTF1, TFAM, TCF6 (for transcription factor 6-like1), TCF6L2 and tsHMG, is a nuclear-encoded gene product that is imported into the mitochondria. mtTFA is required for many aspects of mitochondrial biogenesis including the replication and transcription of mitochondrial DNA (mtDNA). In mouse, testis-specific mtTFA is missing the mitochondria targeting sequence and is present in the nucleus rather than the mitochondria. This form of mtTFA is located primarily in the nuclei of elongated spermatids and may be involved in the regulation of gene expression of the haploid male genome. During mouse and human spermatogenesis there is a reduction of mtTFA protein levels and a reduction in mtDNA copy number. These features may provide one of the mechanisms by which paternal mtDNA transmission is prevented. mtTFA has been associated with mitochondrial disorder in humans characterized by ocular myopathy, exercise intolerance and muscle wasting.

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