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Recombinant Integrase interactor 1 (INI-1) / SNF5 / SMARCB1 Antibody [INI1/8935R]

Additional information

Catalog Number: 6598-RBM15
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
6598-RBM15-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
6598-RBM15-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
6598-RBM15-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant Integrase interactor 1 (INI-1) / SNF5 / SMARCB1 Antibody

Formalin-fixed, paraffin-embedded human ovarian cancer stained with INI-1 Recombinant Rabbit Monoclonal Antibody (INI1/8935R) Inset: PBS instead of primary antibody; secondary only negative control.

SMARCB1 Antibody in SDS-PAGE

SMARCB1 Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 Recombinant Rabbit Monoclonal Antibody (INI1/8935R). Confirmation of Purity and Integrity of Antibody.

INI-1 Antibody in Western Blot (WB)

INI-1 Antibody in Western Blot (WB)

Western Blot Analysis of Human Brain, Human Pancreas, Human Skin, Human Stomach, Human Spleen, A431, Jurkat, K-562 and PC3 lysates using INI-1 Rabbit Recombinant Monoclonal Antibody (INI1/8935R).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
INI1/8935R
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Nucleus
Gene Name
SMARCB1
Positive Control
astrocytoma or kidney.| Human Brain, Human Pancreas, Human Skin, Human Stomach, Human Spleen, A4341, Jurkat, K-562, PC3
Immunogen
Recombinant fragment (around aa1-385) of the human INI-1 (INI1) (Integrase Interactor 1 Protein ) protein (exact sequence is proprietary)
Expression System
CHO
Purification
Protein A
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
6598
SwissProt
Q12824
Chromosome Location
22q11.23|22q11
Mol. Weight of Antigen
44.14kDa
Alternate Names
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1, BAF47|CSS3|INI-1|INI1|MRD15|PPP1R144|RDT|RTPS1|SNF5|SNF5L1|SWNTS1|Sfh1p|Snr1|hSNFS

Summary

The INI-1 gene, which encodes a functionally uncharacterized protein component of the hSWI/SNF chromatin remodeling complex, is often mutated or deleted in malignant rhabdoid tumor (MRT). Two isoforms of INI-1, that differ by the variable inclusion of amino acids, potentially are produced by differential RNA splicing. The morphology of MRTs can present challenges in differential diagnosis. The overall survival of MRTs relative to its potential mimics (medulloblastoma, supratentorial primitive neuroectodermal tumors (sPNETs) is quite low, and thus differentiation from these other tumors is desirable. Lack of nuclear labeling by anti-INI-1 is characteristic of MRT. The majority of medulloblastomas and sPNETs are labeled by anti-INI-1. MRTs also originate from the kidney and soft tissues.

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