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ZC3H7A (Transcription Factor) Antibody [PCRP-ZC3H7A-1D6]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
29066-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
29066-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
29066-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-2ug/ml

Summary

The zinc finger CCCH domain-containing protein 7A (ZC3H7A), also known as ZC3H7, HSPC055 or ZC3HDC7, is a 971 amino acid protein that contains a C3H1-type zinc finger domain, three C3H1-type zinc fingers and three TPR repeats. Belonging to the ZC3H12 family, ZC3H7A localizes to the nucleus. Existing as two alternatively spliced isoforms, ZC3H7A is encoded by a gene located on human chromosome 16p13.13. Chromosome 16 makes up nearly 3% of human cellular DNA and is associated with a variety of genetic disorders. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, though through the CREBBP gene which encodes a critical CREB binding protein. Signs of RubinsteinTaybi include mental retardation and predisposition to tumor growth and white blood cell neoplasias. Crohn s disease is a gastrointestinal inflammatory condition associated with chromosome 16 through the NOD2 gene.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG1 /
Cellular Localization
Nucleus
Gene Name
Positive Control
HeLa or HepG2 cells.
Immunogen
Recombinant full-length human ZC3H7A protein
Alternate Names
Zinc finger CCCH domain-containing protein 7A, Zinc Finger CCCH-Type Containing 7; ZC3HDC7; Zinc Finger CCCH Domain-Containing Protein 7A; HSPC055; FLJ20318; ZC3H7A

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
PCRP-ZC3H7A-1D6
Chromosome Location
16p13.13
Mol. Weight of Antigen
110kDa

Functions

  • May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3'-ATA(A/T)-5' motif in the apical loop.

Key References

  • Blackshaw S, et al. Nature methods 15.5 (2018 May): 330-338.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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