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Recombinant MCAM (Melanoma Cell Adhesion Molecule) / MUC18 / CD146 Antibody [rMUC18/1130]

Additional information

Catalog Number: 4162-MSM5
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
4162-MSM5-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
4162-MSM5-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
4162-MSM5-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
MCAM Antibody in SDS-PAGE

MCAM Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified Cell surface glycoprotein MUC18 Recombinant Mouse Monoclonal Antibody (rMUC18/1130). Confirmation of Purity and Integrity of Antibody.

Recombinant MCAM (Melanoma Cell Adhesion Molecule) / MUC18 / CD146 Antibody - Image 2

Formalin-fixed, paraffin-embedded human Tonsil stained with MUC18 Mouse Recombinant Monoclonal Antibody (rMUC18/1130).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
rMUC18/1130
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Membrane
Gene Name
MCAM
Positive Control
A-375, HUV-EC or HeLa cells. Tonsil or Melanoma (IHC).
Immunogen
Recombinant full-length human CD146 protein
Expression System
HEK293
Purification
Protein G
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
4162
SwissProt
P43121
Chromosome Location
11q23.3
Mol. Weight of Antigen
71.61kDa
Alternate Names
Cell surface glycoprotein MUC18, CD146|HEMCAM|METCAM|MUC18|MelCAM

Summary

Mel-CAM belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

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