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  • Drug Targets, HuProt™ Validated

Recombinant Glucagon (Marker of Glucagonoma) Antibody [GCG/13090R]

Additional information

Catalog Number: 2641-RBM4
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
2641-RBM4-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
2641-RBM4-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
2641-RBM4-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
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Glucagon Antibody in Immunohistochemistry (IHC (P))

Glucagon Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human pancreas stained with Glucagon Recombinant Rabbit Monoclonal Antibody (GCG/13090R). Inset: PBS instead of primary antibody; secondary only negative control.

Glucagon Antibody in SDS-PAGE

Glucagon Antibody in SDS-PAGE

SDS-PAGE Analysis of Purified Glucagon Recombinant Rabbit Monoclonal Antibody (GCG/13090R). Confirmation of Purity and Integrity of Antibody.

Glucagon Antibody in Human Protein Array (HuProt) Analysis

Glucagon Antibody in Human Protein Array (HuProt) Analysis

Analysis of Protein Array containing more than 19,000 full-length human proteins using Glucagon Recombinant Rabbit Monoclonal Antibody (GCG/13090R). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
GCG/13090R
Isotype
IgG
Light Chain
Kappa
Cellular Localization
Cytoplasm, Secreted
Gene Name
GCG
Positive Control
Human pancreas.
Immunogen
Recombinant fragment (around aa1-100) of human GCG protein (exact sequence is proprietary)
Expression System
HEK293
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Glucagon Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. Glucagon-like peptide 1 Potent stimulator of glucose-dependent insulin release. Also stimulates insulin release in response to IL6 (PubMed:22037645). Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis (Probable). Glucagon-like peptide 2 Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability. Oxyntomodulin Significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness. Glicentin May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.
Key References
  • Kolb et al (2009). Glucagon/insulin ratio as a potential biomarker for pancreatic cancer in patients with new-onset diabetes mellitus. Cancer biology & therapy, 8(16), 1527–1533. https://doi.org/10.4161/cbt.8.16.9006
  • Janah, L., Kjeldsen, S., et al. (2019). Glucagon Receptor Signaling and Glucagon Resistance. International journal of molecular sciences, 20(13), 3314. https://doi.org/10.3390/ijms20133314
  • Thakkar, A., Wang, B. et al. (2016). Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer. Breast cancer research and treatment, 157(1), 77–90. https://doi.org/10.1007/s10549-016-3807-y
  • Capozzi, M. E., D'Alessio, D. A., & Campbell, J. E. (2022). The past, present, and future physiology and pharmacology of glucagon. Cell metabolism, 34(11), 1654–1674. https://doi.org/10.1016/j.cmet.2022.10.001
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
2641
SwissProt
P01275
Chromosome Location
2q24.2
Mol. Weight of Antigen
19kDa (Proglucagon); 3kDa (Glucagon)
Alternate Names
Pro-glucagon, Glicentin; Glicentin-related polypeptide (GRPP); Oxyntomodulin (OXM; OXY); Glucagon; Glucagon-like peptide 1 (GLP-1); Alternative names: Incretin hormone Glucagon-like peptide 1(7-37) (GLP-1(7-37)); Glucagon-like peptide 1(7-36) (GLP-1(7-36)); Glucagon-like peptide 2 (GLP-2), GLP1; GLP2; GRPP; GLP-1

Summary

Glucagon is a pancreatic hormone that functions as an antagonist to Insulin, stimulating the conversion of glycogen to glucose and increasing blood sugar levels. Glucagon-like peptide-1 (GLP-1), Glucagon-like peptide-2 (GLP-2), VIP (vasoactive intestinal peptide) and PACAP (pituitary adenylate cyclase activating polypeptide) are members of the Glucagon family of hormones. GLP-1 functions as a transmitter in the central nervous system, inhibiting feeding and drinking behavior, whereas GLP-2 is a stimulator of intestinal epithelial growth. VIP causes vasodilation resulting in the lowering of blood pressure. PACAP is abundant in the hypothalamus and has been shown to increase the synthesis of several hormones, including growth hormone. Glucagon antibody detects glucagon-secreting cells and tumors such as glucagonomas, of which approximately 80% are malignant.

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