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Recombinant C-type lectin domain family 4 member M Antibody [CD299/9665R]

In Stock
Catalog Number Formulation Size Price
10332-RBM4-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
10332-RBM4-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
10332-RBM4-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
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Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml
Western Blot Protocol

Summary

Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates., (Microbial infection) Acts as an attachment receptor for Ebolavirus., (Microbial infection) Acts as an attachment receptor for Hepatitis C virus., (Microbial infection) Acts as an attachment receptor for HIV-1., (Microbial infection) Acts as an attachment receptor for Human coronavirus 229E., (Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5., (Microbial infection) Acts as an attachment receptor for Influenzavirus., (Microbial infection) Acts as an attachment receptor for SARS-CoV., (Microbial infection) Acts as an attachment receptor for West-nile virus., (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus., (Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein., (Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule.

Product Properties & Targets

Antibody Type
Recombinant Rabbit Monoclonals
Host
Rabbit
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Isotype / Light Chain
IgG / Kappa
Cellular Localization
Cell membrane, Secreted
Gene Name
CLEC4M
Positive Control
Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node
Immunogen
Recombinant full-length human CD299 protein
Alternate Names
C-type lectin domain family 4 member M, CD209L|CD299|DC-SIGN2|DC-SIGNR|DCSIGNR|HP10347|L-SIGN|LSIGN

Database Links

Entrez Gene ID
10332
SwissProt
Q9H2X3

Additional Information

Clone
CD299/9665R
Chromosome Location
19p13.2
Mol. Weight of Antigen
45.35kDa
Expression System
CHO Cells
Purification
Protein A

Related Antibodies

View All CLEC4M Antibodies

Functions

  • Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates., (Microbial infection) Acts as an attachment receptor for Ebolavirus., (Microbial infection) Acts as an attachment receptor for Hepatitis C virus., (Microbial infection) Acts as an attachment receptor for HIV-1., (Microbial infection) Acts as an attachment receptor for Human coronavirus 229E., (Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5., (Microbial infection) Acts as an attachment receptor for Influenzavirus., (Microbial infection) Acts as an attachment receptor for SARS-CoV., (Microbial infection) Acts as an attachment receptor for West-nile virus., (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus., (Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein., (Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
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