Interferon gamma (IFNG) Antibody [SPM153]

• Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:16914093, PubMed:8666937). Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation (PubMed:8349687). Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription (PubMed:16914093). Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits (PubMed:8666937). In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading (PubMed:8163024). Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference (PubMed:11112687). Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (PubMed:7729559). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (By similarity).

• Farrar MA and Schreiber RD. The molecular cell biology of interferon-gamma and its receptor. Annu Rev Immunol 1993, 11:571-611
• Vilcek J. Forty years of interferon, forty years of cytokines. Cytokine Growth Factor Rev 1997,8(4):239
• Vilcek J et al. Induction of human interferon gamma with phorbol esters and phytohemagglutinin. Methods Enzymol 1986,119:48-54

• https://pubmed.ncbi.nlm.nih.gov/6180322/
• https://pubmed.ncbi.nlm.nih.gov/6173769/
• https://pubmed.ncbi.nlm.nih.gov/2860101/
• https://pubmed.ncbi.nlm.nih.gov/6329718/
• https://pubmed.ncbi.nlm.nih.gov/6176945/
• https://pubmed.ncbi.nlm.nih.gov/19054851/
• https://pubmed.ncbi.nlm.nih.gov/15489334/
• https://pubmed.ncbi.nlm.nih.gov/6427223/
• https://pubmed.ncbi.nlm.nih.gov/3109913/
• https://pubmed.ncbi.nlm.nih.gov/2504704/
• https://pubmed.ncbi.nlm.nih.gov/8349687/
• https://pubmed.ncbi.nlm.nih.gov/8163024/
• https://pubmed.ncbi.nlm.nih.gov/7729559/
• https://pubmed.ncbi.nlm.nih.gov/8666937/
• https://pubmed.ncbi.nlm.nih.gov/9643557/
• https://pubmed.ncbi.nlm.nih.gov/11112687/
• https://pubmed.ncbi.nlm.nih.gov/16914093/
• https://pubmed.ncbi.nlm.nih.gov/32163377/
• https://pubmed.ncbi.nlm.nih.gov/1902591/
• https://pubmed.ncbi.nlm.nih.gov/7617032/
• https://pubmed.ncbi.nlm.nih.gov/10860730/
• https://pubmed.ncbi.nlm.nih.gov/10986460/
• https://pubmed.ncbi.nlm.nih.gov/1525157/
• https://pubmed.ncbi.nlm.nih.gov/15327519/

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3458

P01579

12q14

20-25kDa

Interferon gamma, Immune interferon, AMCF1; Beta thromboglobulin like protein; CXC chemokine ligand 8 (CXCL8); Emoctakin; Granulocyte chemotactic protein 1 (GCP1); IFG; IFI; IFN Immune; IFN-gamma (IFNG); Interleukin 8; Interferon gamma; LECT; LUCT; Lymphocyte derived neutrophil activating factor; LYNAP; Macrophage Activating Factor (MAF); Monocyte derived neutrophil activating protein (MONAP); Monocyte derived neutrophil chemotactic factor (MDNCF); Neutrophil activating factor (NAF); Neutrophil activating peptide 1 (NAP1); Neutrophil activating protein 1 (NAP1); SCYB8; T cell chemotactic factor; T Cell Interferon; Type II Interferon