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Guanine nucleotide-binding protein alpha-q / GNAQ / G-ALPHA-q Antibody [GNAQ/2434]

In Stock
Catalog Number Formulation Size Price
2776-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
2776-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
2776-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-2ug/ml

Summary

GNAQis 359 amino acids long and is identical in all but 1 amino acid residue to the Mouse protein. Analysis of human genomic DNA revealed an intronless sequence with strong homology to human GNAQ cDNA. In comparison to GNAQ cDNA, this genomic DNA sequence included several small deletions and insertions that altered the reading frame, multiple single based changes, and a premature termination codon in the open reading frame, all hallmarks of a processed pseudogene. Probes derived from human GNAQ cDNA sequence mapped both chromosomes 2 and 9 in higher constringency genomic blot analyses of DNA from a panel of human/rodent hybrid cell lines.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG2b / Kappa
Cellular Localization
Cell membrane, Golgi apparatus, Nucleus, Nucleus membrane
Gene Name
Positive Control
HL-60, MOLT-4 and MCF-7 cells. Predominantly expressed in ovary, prostate, testis and colon.
Immunogen
Recombinant full-length human GNAQ protein
Alternate Names
Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein alpha-q, CMC1; G alpha Q; G protein alpha Q; GAQ; guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding protein G(q) subunit alpha; SWS

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
GNAQ/2434
Chromosome Location
9q21.2
Mol. Weight of Antigen
45kDa

Functions

  • Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro) (By similarity). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs).

Key References

  • Strathmann, M. and Simon, M.I. 1990. Proc. Natl. Acad. Sci. USA 87: 9113-9117.
  • Simon, M.I., et al. 1991. Diversity of G proteins in signal transduction. Science 252: 802-808.
  • Chen, B., et al. 1996. Biochim. Biophys. Acta 1281:125-128

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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