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GLIS family zinc finger 3 (GLIS3) / ZNF515 Antibody [PCRP-GLIS3-1B11]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
169792-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
169792-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
169792-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Flow Cytometry (Flow)
1-2ug/million cells

Summary

GLIS3 is a member of the GLI similar zinc finger protein family, and encodes a nuclear protein with five C2H2 type zinc finger domains. It functions as both an activator and repressor of transcription, and is specifically involved in the development of pancreatic beta cells, thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full length nature of only two have been determined.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Research Areas
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Nucleus
Gene Name
Positive Control
A549 or U-2 OS cells.
Immunogen
Recombinant full-length human GLIS3 protein
Alternate Names
Zinc finger protein GLIS3, GLI-similar 3, Zinc finger protein 515, FLJ38999; FLJ90578; GLI similar 3; GLI SIMILAR PROTEIN 3; GLIS family zinc finger 3; MGC33662; OK/KNS-cl.4; Zinc finger protein 515; Zinc finger protein GLIS3; ZNF515

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
PCRP-GLIS3-1B11
Chromosome Location
9p24.2
Mol. Weight of Antigen
84kDa

Functions

  • Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity).

Key References

  • Kim, Y.S., et al. 2003. GLIS3, a novel member of the GLIS subfamily of Kr ppel-like zinc-finger proteins with repressor and activation functions. Nucleic Acids Res. 31: 5513-5525.

Storage & Stability

Antibody with azide store at 2 to 8 °C. Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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