GLIS family zinc finger 3 (GLIS3) / ZNF515 [PCRP-GLIS3-1B11]



GLIS3 is a member of the GLI similar zinc finger protein family, and encodes a nuclear protein with five C2H2 type zinc finger domains. It functions as both an activator and repressor of transcription, and is specifically involved in the development of pancreatic beta cells, thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full length nature of only two have been determined.

Product Properties & Targets

Species Reactivity
Cellular Localization
Light Chain
Gene Name
Positive Control
A549 or U-2 OS cells.
Recombinant full-length human GLIS3 protein
Alternate Names
Zinc finger protein GLIS3, GLI-similar 3, Zinc finger protein 515, FLJ38999; FLJ90578; GLI similar 3; GLI SIMILAR PROTEIN 3; GLIS family zinc finger 3; MGC33662; OK/KNS-cl.4; Zinc finger protein 515; Zinc finger protein GLIS3; ZNF515

Database Links

Entrez Gene ID

Additional Information

Human Gene Symbol
Chromosome Location
Mol. Weight of Antigen


  • Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3' (By similarity).

Known Applications & Suggested Dilutions

  • ELISA (For coating, order antibody without BSA)
  • ,Flow Cytometry (1-2ug/million cells)
  • ,Immunoprecipitation (1-2ug per 100-500ug of total protein (1ml of cell lysate))
  • ,Optimal dilution for a specific application should be determined.

Key References

  • Kim, Y.S., et al. 2003. GLIS3, a novel member of the GLIS subfamily of Kr ppel-like zinc-finger proteins with repressor and activation functions. Nucleic Acids Res. 31: 5513-5525.

Storage & Stability

Antibody with azide store at 2 to 8 °C. Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.


This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.


There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.


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