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GIRK2 (Interleukin-6) / Interferon beta-2 (Hybridoma Growth Factor) Antibody [KCNJ6/7559]

Additional information

Catalog Number: 3763-MSM3
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
3763-MSM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
3763-MSM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
3763-MSM3-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
GIRK2 (Interleukin-6) / Interferon beta-2 (Hybridoma Growth Factor) Antibody

SDS-PAGE Analysis of Purified GIRK2 Mouse Monoclonal Antibody (KCNJ6/7559). Confirmation of Purity and Integrity of Antibody.

GIRK2 (Interleukin-6) / Interferon beta-2 (Hybridoma Growth Factor) Antibody - Image 2

Formalin-fixed, paraffin-embedded human brain stained with GIRK2 Mouse Monoclonal Antibody (KCNJ6/7559) at 2ug/ml. HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
KCNJ6/7559
Isotype
IgG2
Light Chain
Kappa
Cellular Localization
Membrane.
Gene Name
KCNJ6
Positive Control
Human brain or pancreas.
Immunogen
Recombinant fragment of human KCNJ6 protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Key References
  • Schein JC, Hunter DD, Roffler-Tarlov S. Girk2 expression in the ventral midbrain, cerebellum, and olfactory bulb and its relationship to the murine mutation weaver.Dev Biol. 1998;204(2):432-450. doi:10.1006/dbio.1998.9076
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
3763
SwissProt
P48051Human
Chromosome Location
21q22.13
Mol. Weight of Antigen
48kDa
Alternate Names
G protein-activated inward rectifier potassium channel 2, BIR1, Inward rectifier K(+) channel Kir3.2, KATP-2, Potassium channel, inwardly rectifying subfamily J member 6, inwardly rectifying subfamily J member 6; BIR1; G protein activated inward rectifier potassium channel 2; GIRK2; hiGIRK2; Inward rectifier K(+) channel Kir3.2; Inward rectifier potassium channel KIR3.2; KATP2; KCNJ6; Kcnj7; KIR3.2; KPLBS; Potassium inwardly rectifying channel subfamily J member 6; Potassium voltage gated channel subfamily J member 6

Summary

This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulation. Mutations in this gene are associated with Keppen-Lubinsky Syndrome, a rare condition characterized by severe developmental delay, facial dysmorphism, and intellectual disability. [provided by RefSeq, Apr 2015]

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