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Gelsolin / Actin-depolymerizing Factor Antibody [CPTC-Gelsolin-1]

In Stock
Catalog Number Formulation Size Price
2934-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
2934-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
2934-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Western Blot (WB)
2-4ug/ml

Summary

Gelsolin (also known as brevin, Actin-depolymerizing factor or ADF), a proteinof leukocytes, platelets and other cells, severs Actin filaments in thepresence of submicromolar calcium, thereby isolating cytoplasmic Actin gels. It is a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. Defects in GSN are the cause of amyloidosis type 5 (AMYL5); also known as familial amyloidosis Finnish type, typically characterized by cranial neuropathy and lattice corneal dystrophy. Severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Research Areas
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cytoplasm, Cytoskeleton, Secreted
Gene Name
GSN
Positive Control
MCF cell lysate, Tonsil.
Immunogen
Recombinant human full-length protein
Alternate Names
Gelsolin, AGEL, Actin-depolymerizing factor, Brevin, Actin depolymerizing factor; ADF; AGEL; Brevin; Gsn

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
CPTC-Gelsolin-1
Chromosome Location
9q33.2
Mol. Weight of Antigen
~90kDa

Functions

  • Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.

Key References

  • Lind, S.E., et al. 1984. Human plasma Gelsolin binds to Fibronectin. J. Biol.
  • Chem. 259: 13262-13266.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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