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Gelsolin / Actin-depolymerizing Factor Antibody [CPTC-Gelsolin-1]

Additional information

Catalog Number: 2934-MSM1
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
2934-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
2934-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
2934-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Gelsolin Antibody in SDS-page

Gelsolin Antibody in SDS-page

SDS-PAGE Analysis Purified Gelsolin Mouse Monoclonal Antibody (CPTC-Gelsolin-1). Confirmation of Purity and Integrity of Antibody.

  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Western Blot
Species Reactivity
Human
Clone
CPTC-Gelsolin-1
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cytoplasm, Cytoskeleton, Secreted
Gene Name
GSN
Positive Control
MCF cell lysate, Tonsil.
Immunogen
Recombinant human full-length protein
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Formalin-fixed, paraffin-embedded human Colon stained with CDH17-Monospecific Mouse Monoclonal Antibody (CDH17/2615).
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VIEW ALL ANTIBODIES

Other Information

Functions
  • Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis.
Key References
  • Lind, S.E., et al. 1984. Human plasma Gelsolin binds to Fibronectin. J. Biol.
  • Chem. 259: 13262-13266.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
2934
SwissProt
P06396
Chromosome Location
9q33.2
Mol. Weight of Antigen
~90kDa
Alternate Names
Gelsolin, AGEL, Actin-depolymerizing factor, Brevin, Actin depolymerizing factor; ADF; AGEL; Brevin; Gsn

Summary

Gelsolin (also known as brevin, Actin-depolymerizing factor or ADF), a proteinof leukocytes, platelets and other cells, severs Actin filaments in thepresence of submicromolar calcium, thereby isolating cytoplasmic Actin gels. It is a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. Defects in GSN are the cause of amyloidosis type 5 (AMYL5); also known as familial amyloidosis Finnish type, typically characterized by cranial neuropathy and lattice corneal dystrophy. Severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.

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