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GCM2 Antibody [PCRP-GCM2-1B3]

In Stock
Catalog Number Formulation Size Price
9247-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
9247-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
9247-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $75 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-3ug/ml

Summary

Glial cells missing homolog 2 (GCM2), also known as Chorion-specific transcription factor GCMb, is a 506 amino acid nuclear protein. GCM2 is a transcription factor that acts as an essential regulator of parathyroid development. GCM2 is also thought to mediate the effect of calcium on parathyroid hormone expression and secretion in parathyroid cells. GCM2 contains one N-terminal GCM domain, which has DNA binding activity. Mutations of the gene that encodes GCM2 are associated with hypoparathyroidism, an autosomal recessive condition characterized by hypocalcemia and hyperphosphatemia.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG2b /
Cellular Localization
Nucleus
Gene Name
Positive Control
HeLa or MCF-7 cells.
Immunogen
Recombinant human GCM2 protein
Alternate Names
Chorion-specific transcription factor GCMb, GCM motif protein 2, Glial cells missing homolog 2, hGCMb | GCMB

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
PCRP-GCM2-1B3
Chromosome Location
3q27.3
Mol. Weight of Antigen
56.61kDa

Functions

  • Transcription factor that binds specific sequences on gene promoters and activate their transcription. Through the regulation of gene transcription, may play a role in parathyroid gland development.

Key References

  • Garcia JF,et al.2006.J. Histochem Cytochem.54:31.
  • Pasqualucci, L., et al. 2003. Leuk. Lymphoma 44 Suppl 3: S5-12.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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