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FTCD / 58K Golgi Protein Antibody [FTCD/357]

In Stock
Catalog Number Formulation Size Price
10841-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
10841-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
10841-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-3ug/ml
Western Blot (WB)
2-4ug/ml

Summary

The antibody recognizes an epitope located on the microtubule-binding peripheral Golgi membrane 58 kDa protein. It is also useful for studies on the effect of microtubule-perturbing agents on the Golgi apparatus.The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively-spliced transcript variants have been found for this gene. Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool. Binds and promotes bundling of vimentin filaments originating from the Golgi.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Research Areas
Isotype / Light Chain
IgG1 /
Cellular Localization
Centriole, Centrosome, Cytoplasm, Cytoskeleton, Cytosol, Golgi apparatus, Microtubule organizing center
Gene Name
Positive Control
HeLa or HepG2 cells. Human kidney or liver tissue.
Immunogen
58K Golgi Protein purified from rat liver.
Alternate Names
Formimidoyltransferase-cyclodeaminase, Formiminotransferase-cyclodeaminase, LCHC1, Formimidoyltetrahydrofolate cyclodeaminase; Formiminotetrahydrofolate cyclodeaminase; Formiminotransferase cyclodeaminase; Glutamate formiminotransferase; Glutamate formyltransferase; LCHC1

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
FTCD/357
Chromosome Location
21q22.3
Mol. Weight of Antigen
59kDa

Functions

  • Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.
  • Binds and promotes bundling of vimentin filaments originating from the Golgi.

Key References

  • Hennig, D., et al. 1998. A formiminotransferase cyclodeaminase isoform is localized to the Golgi complex and can mediate interaction of trans-Golgi network-derived vesicles with microtubules. J. Biol. Chem. 273:19602-19611.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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