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FOLH1 / PSMA (Prostate Epithelial Marker) Antibody [FOLH1/2121]

Additional information

Catalog Number: 2346-MSM1
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
2346-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
2346-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
2346-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
FOLH1 / PSMA (Prostate Epithelial Marker) Antibody

SDS-PAGE Analysis of Purified FOLH1 Mouse Monoclonal Antibody (FOLH1/2121). Confirmation of Purity and Integrity of Antibody.

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  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
ELISA
Species Reactivity
Human
Clone
FOLH1/2121
Isotype
IgG2b
Light Chain
Kappa
Cellular Localization
Cell membrane, Cytoplasm
Gene Name
FOLH1
Positive Control
LNCap or HepG2 cells. Prostate Carcinoma.
Immunogen
Recombinant human FOLH1 protein fragment (around aa 232-433) (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Additional information

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Reactivity:

, , , ,

Gene:

Host:

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.
  • Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.
Key References
  • Israeli, R.S., et al. 1993. Cancer Res. 53: 227-230.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
2346
SwissProt
Q04609
Chromosome Location
11p11.12
Mol. Weight of Antigen
100kDa
Alternate Names
Glutamate carboxypeptidase 2, Cell growth-inhibiting gene 27 protein, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, N-acetylated-alpha-linked acidic dipeptidase I, Prostate-specific membrane antigen, Pteroylpoly-gamma-glutamate carboxypeptidase, Cell growth-inhibiting gene 27 protein (GIG27); Folylpoly-gamma-glutamate carboxypeptidase (FGCP); Glutamate carboxylase II (GCPII); N-acetylated-alpha-linked acidic dipeptidase I (NAALAD1 or NAALADase); Prostate-specific membrane antigen (PSM or PSMA); Pteroylpoly-gamma-glutamate carboxypeptidase

Summary

Folate hydrolase 1 (FOLH1), also known as Prostate-specific membrane antigen (PSMA), is a type II transmembrane glycoprotein belonging to the M28 peptidase family. FOLH1 has two enzymatic activities, one as a prostate-specific integral membrane folate hydrolase and the other as a carboxypeptidase In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer.

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