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Fatty Acid Binding Protein (Liver) / FABP1 Antibody [FABP1/4518]

In Stock
Catalog Number Formulation Size Price
2168-MSM18-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
2168-MSM18-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
2168-MSM18-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Western Blot (WB)
2-4ug/ml

Summary

Fatty acid-binding proteins, designated FABPs, are a family of homologous cytoplasmic proteins that are expressed in a highly tissue-specific manner and play an integral role in the balance between lipid and carbohydrate metabolism. FABPs mediate fatty acid (FA) and/or hydrophobic ligand uptake, transport and targeting within their respective tissues. The mechanisms underlying these actions can give rise to both passive diffusional uptake and protein-mediated transmembrane transport of FAs. FABPs are expressed in adipocytes (A-FABP), brain (B-FABP), epithelium (E-FABP, psoriasis-associated FABP, PA-FABP), striated muscle and heart (H-FABP, mammary-derived growth inhibitor or MDGI), intestine (I-FABP), liver (L-FABP or FABP1), myelin (M-FABP) and testis (T-FABP). FABP1 (L-FABP) expression is modulated by developmental, hormonal, dietary and pharmacological factors, and is required for cholesterol synthesis and metabolism.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Research Areas
Isotype / Light Chain
IgG2 / Kappa
Cellular Localization
Cytoplasm
Gene Name
Positive Control
Human kidney tissue lysate (WB).
Immunogen
Human recombinant FABP1 protein fragment (around aa1-127) (exact sequence is proprietary)
Alternate Names
Fatty acid-binding protein, liver, Fatty acid-binding protein 1, Liver-type fatty acid-binding protein, FABP1, L-FABP

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
FABP1/4518
Chromosome Location
2p11.2
Mol. Weight of Antigen
14kDa

Functions

  • Plays a role in lipoprotein-mediated cholesterol uptake in hepatocytes (PubMed:25732850). Binds cholesterol (PubMed:25732850). Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport (By similarity).

Key References

  • Kaikaus, R.M., et al. 1993. Mechanisms of regulation of liver fatty acid binding protein. Mol. Cell. Biochem. 123: 93-100.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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