Formalin-fixed, paraffin-embedded human Pancreas stained with Elastin Mouse Monoclonal Antibody (ELN/2069).

Formalin-fixed, paraffin-embedded human Small Intestine stained with Elastin Mouse Monoclonal Antibody (ELN/2069).

Formalin-fixed, paraffin-embedded human Angiosarcoma stained with Elastin Mouse Monoclonal Antibody (ELN/2069).

SDS-PAGE Analysis Purified Elastin Mouse Monoclonal Antibody (ELN/2069). Confirmation of Integrity and Purity of Antibody.

Printable Datasheet

Elastin (ELN) (Marker of Arterial Stiffness and Atherosclerosis) [ELN/2069]

Name: Elastin (ELN) (Marker of Arterial Stiffness and Atherosclerosis)
SKU: 2006-MSM2
Availability: InStock

Monoclonals Mouse Monoclonals Primary Antibodies

Summary

Elastin is a polymeric protein and is the main component of the extracellular matrix of arteries.It is synthesized and secreted as a soluble, single-chain protein (tropoelastin), which undergoes a number of post-translational modifications prior to its organization into an elastic fiber in the extracellular space. Elastin performs a regulatory function during arterial development by controlling proliferation of smooth muscle and stabilizing arterial structure. It imparts elasticityto the connective tissue. During aging, the elasticity of connective tissue is reduced because of the cross-linking of collagenous fibers with elastin. The abnormal accumulation of elastic tissue in blood vessels is found in atherosclerosis and hypertension.

Product Properties & Targets

Host

Mouse

Species Reactivity

Human

Isotype

IgG1

Cellular Localization

Extracellular matrix, Extracellular space, Secreted

Light Chain

kappa

Gene Name

ELN

Positive Control

A549 or U-2197 cells. Liver, Kidney, Lung or Intestine.

Immunogen

Recombinant full-length human Elastin protein

Alternate Names

Elastin, Tropoelastin, Elastin; ELN; SVAS; Tropoelastin; WBS; WS

Database Links

Entrez Gene ID

2006

Unigene

647061

SwissProt

P15502

Additional Information

Clone

ELN/2069

Human Gene Symbol

ELN

Chromosome Location

7q11.23

Mol. Weight of Antigen

70kDa

Functions

Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity).

Known Applications & Suggested Dilutions

ELISA (For coating, order Ab without BSA)
,Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 min at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95&degC followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Key References

Fazio, M.J., et al. 1991. Human elastin gene: new evidence for localization to the long arm of chromosome 7. Am. J. Hum. Genet. 48: 696-703.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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