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Elastin (ELN) (Marker of Arterial Stiffness and Atherosclerosis) Antibody [ELN/2069]

Additional information

Catalog Number: 2006-MSM2
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
2006-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
2006-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
2006-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Elastin (ELN) (Marker of Arterial Stiffness and Atherosclerosis) Antibody

Formalin-fixed, paraffin-embedded human Pancreas stained with Elastin Mouse Monoclonal Antibody (ELN/2069).

Elastin (ELN) (Marker of Arterial Stiffness and Atherosclerosis) Antibody - Image 2

Formalin-fixed, paraffin-embedded human Small Intestine stained with Elastin Mouse Monoclonal Antibody (ELN/2069).

Elastin (ELN) (Marker of Arterial Stiffness and Atherosclerosis) Antibody - Image 3

Formalin-fixed, paraffin-embedded human Angiosarcoma stained with Elastin Mouse Monoclonal Antibody (ELN/2069).

Elastin (ELN) (Marker of Arterial Stiffness and Atherosclerosis) Antibody - Image 4

SDS-PAGE Analysis of Purified Elastin Mouse Monoclonal Antibody (ELN/2069). Confirmation of Integrity and Purity of Antibody.

  • ELISA
  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
ELISA, Immunohistochemistry
Species Reactivity
Human
Clone
ELN/2069
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Extracellular matrix, Extracellular space, Secreted
Gene Name
ELN
Positive Control
A549 or U-2197 cells. Liver, Kidney, Lung or Intestine.
Immunogen
Recombinant full-length human Elastin protein
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity).
Key References
  • Fazio, M.J., et al. 1991. Human elastin gene: new evidence for localization to the long arm of chromosome 7. Am. J. Hum. Genet. 48: 696-703.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
2006
SwissProt
P15502
Chromosome Location
7q11.23
Mol. Weight of Antigen
70kDa
Alternate Names
Elastin, Tropoelastin, Elastin; ELN; SVAS; Tropoelastin; WBS; WS

Summary

Elastin is a polymeric protein and is the main component of the extracellular matrix of arteries.It is synthesized and secreted as a soluble, single-chain protein (tropoelastin), which undergoes a number of post-translational modifications prior to its organization into an elastic fiber in the extracellular space. Elastin performs a regulatory function during arterial development by controlling proliferation of smooth muscle and stabilizing arterial structure. It imparts elasticityto the connective tissue. During aging, the elasticity of connective tissue is reduced because of the cross-linking of collagenous fibers with elastin. The abnormal accumulation of elastic tissue in blood vessels is found in atherosclerosis and hypertension.

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