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DLL3 / SCDO1 Antibody [DLL3/9361]

In Stock
Catalog Number Formulation Size Price
10683-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
10683-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
10683-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day
DLL3 Antibody in SDS-PAGE

DLL3 Antibody in SDS-PAGE

SDS-PAGE Analysis Purified DLL3 Mouse Monoclonal Antibody (DLL3/9361). Confirmation of Purity and Integrity of Antibody.

DLL3 Antibody in Immunohistochemistry (IHC (P))

DLL3 Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human brain stained with DLL3 Mouse Monoclonal Antibody (DLL3/9361). Inset: PBS instead of primary antibody; secondary only negative control.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Cell Biology, Developmental Biology, Epigenetics, Neuroscience, Lung Cancer
Isotype / Light Chain
IgG2c / Kappa
Cellular Localization
Cell surface, Membrane
Gene Name
DLL3
Positive Control
Human small cell lung cancer or brain.
Immunogen
Recombinant fragment (around aa400-618) of human DLL3 protein (exact sequence is proprietary)
Alternate Names
delta-like protein 3, Delta Drosophila like 3 antibody; Delta like 3 Drosophila antibody; Delta like 3 homolog Drosophila antibody; Delta like 3 protein antibody; Delta like protein 3 precursor antibody; Delta-like protein 3 antibody; Delta3 antibody; Dll3 antibody; DLL3_HUMAN antibody; Drosophila Delta homolog 3 antibody; SCDO1 antibody; SCOD1 antibody; Spondylocostal dysostosis autosomal recessive antibody, SCDO1

Database Links

Entrez Gene ID
10683
SwissProt
Q9NYJ7

Additional Information

Clone
DLL3/9361
Chromosome Location
19q13.2
Mol. Weight of Antigen
65kDa

Related Antibodies

View All DLL3 Antibodies

Functions

  • Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.

Key References

  • Owen DH, Giffin MJ, Bailis JM, Smit MD, Carbone DP, He K. DLL3: an emerging target in small cell lung cancer. J Hematol Oncol. 2019;12(1):61. Published 2019 Jun 18. doi:10.1186/s13045-019-0745-2
  • Chou J, Egusa EA, Wang S, et al. Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer. Cancer Res. 2023;83(2):301-315. doi:10.1158/0008-5472.CAN-22-1433
  • Rudin CM, Reck M, Johnson ML, et al. Emerging therapies targeting the delta-like ligand 3 (DLL3) in small cell lung cancer. J Hematol Oncol. 2023;16(1):66. Published 2023 Jun 24. doi:10.1186/s13045-023-01464-y
  • Jaspers JE, Khan JF, Godfrey WD, et al. IL-18-secreting CAR T cells targeting DLL3 are highly effective in small cell lung cancer models. J Clin Invest. 2023;133(9):e166028. Published 2023 May 1. doi:10.1172/JCI166028

PubMed Links

Storage & Stability

Antibody with azide - store at 4 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

Antibody Purified from Bioreactor Concentrate by Protein A/G and conjugated to various reporter molecules. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide. Contact us if you require this Ab in a different format.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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