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DLL3 / SCDO1 Antibody [DLL3/9361]

Additional information

Catalog Number: 10683-MSM1
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
10683-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
10683-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
10683-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
DLL3 Antibody in SDS-PAGE

DLL3 Antibody in SDS-PAGE

SDS-PAGE Analysis Purified DLL3 Mouse Monoclonal Antibody (DLL3/9361). Confirmation of Purity and Integrity of Antibody.

DLL3 Antibody in Immunohistochemistry (IHC (P))

DLL3 Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human brain stained with DLL3 Mouse Monoclonal Antibody (DLL3/9361). Inset: PBS instead of primary antibody; secondary only negative control.

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
DLL3/9361
Isotype
IgG2c
Light Chain
Kappa
Cellular Localization
Cell surface, Membrane
Gene Name
DLL3
Positive Control
Human small cell lung cancer or brain.
Immunogen
Recombinant fragment (around aa400-618) of human DLL3 protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 4 to 8°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
Key References
  • Owen DH, Giffin MJ, Bailis JM, Smit MD, Carbone DP, He K. DLL3: an emerging target in small cell lung cancer. J Hematol Oncol. 2019;12(1):61. Published 2019 Jun 18. doi:10.1186/s13045-019-0745-2
  • Chou J, Egusa EA, Wang S, et al. Immunotherapeutic Targeting and PET Imaging of DLL3 in Small-Cell Neuroendocrine Prostate Cancer. Cancer Res. 2023;83(2):301-315. doi:10.1158/0008-5472.CAN-22-1433
  • Rudin CM, Reck M, Johnson ML, et al. Emerging therapies targeting the delta-like ligand 3 (DLL3) in small cell lung cancer. J Hematol Oncol. 2023;16(1):66. Published 2023 Jun 24. doi:10.1186/s13045-023-01464-y
  • Jaspers JE, Khan JF, Godfrey WD, et al. IL-18-secreting CAR T cells targeting DLL3 are highly effective in small cell lung cancer models. J Clin Invest. 2023;133(9):e166028. Published 2023 May 1. doi:10.1172/JCI166028
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
10683
SwissProt
Q9NYJ7
Chromosome Location
19q13.2
Mol. Weight of Antigen
65kDa
Alternate Names
delta-like protein 3, Delta Drosophila like 3 antibody; Delta like 3 Drosophila antibody; Delta like 3 homolog Drosophila antibody; Delta like 3 protein antibody; Delta like protein 3 precursor antibody; Delta-like protein 3 antibody; Delta3 antibody; Dll3 antibody; DLL3_HUMAN antibody; Drosophila Delta homolog 3 antibody; SCDO1 antibody; SCOD1 antibody; Spondylocostal dysostosis autosomal recessive antibody, SCDO1

Summary

This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene.

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