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CLEC9A / DNGR1 (Dendritic Cell Marker) Antibody [8F9]

Additional information

Catalog Number: 283420-MSM2
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
283420-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
283420-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
283420-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
CLEC9A / DNGR1 (Dendritic Cell Marker) Antibody

SDS-PAGE Analysis of Purified CLEC9A Mouse Monoclonal Antibody (8F9). Confirmation of Integrity and Purity of Antibody.

  • ELISA
  • Flow
  • IF
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
ELISA, Flow Cytometry, Immunofluorescence
Species Reactivity
Human
Clone
8F9
Isotype
IgG2a
Light Chain
Kappa
Cellular Localization
Membrane
Gene Name
CLEC9A
Positive Control
MCF-7 cells (FACS/IF).
Immunogen
RBL-2H3 cells expressing human DNGR-1 fused to an HA epitope
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.
Key References
  • Drickamer, K. 1999. Curr. Opin. Struct. Biol. 9: 585-590.
  • Huysamen, C., et al. 2008. J. Biol. Chem. 283: 16693-16701
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
283420
SwissProt
Q6UXN8
Chromosome Location
12p13.2
Mol. Weight of Antigen
27kDa
Alternate Names
C-type lectin domain family 9 member A, C-type lectin domain family 9 member A (CLEC9A); DNGR1

Summary

This MAb recognizes a protein of 27kDa, identified as CLEC9A (C-type lectin domain family 9 member A). Its epitopes maps in aa 50-110. The C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily consists of a variety of proteins that share a common protein fold and have diverse functions, including cell-cell signaling, cell adhesion, glycoprotein turnover and immune responses. CLEC-9A, also known as DNGR1 (dendritic cell natural killer lectin group receptor 1), is a 241 amino acid single-pass type II membrane protein that contains one C-type lectin domain and belongs to the CTL/CTLD superfamily. Expressed in myeloid lineage cells, brain, spleen and thymus, CLEC-9A is a group V C-type lectin- like receptor (CTLR) that acts as an activation receptor.

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