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CFL2 / NEM7 Antibody [CFL2/9963]

In Stock
Catalog Number Formulation Size Price
1073-MSM3-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
1073-MSM3-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
1073-MSM3-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day
CFL2 Antibody in SDS-PAGE-1.jpg

CFL2 Antibody in SDS-PAGE-1.jpg

SDS-PAGE Analysis Purified CFL2 Mouse Monoclonal Antibody (CFL2/9963). Confirmation of Purity and Integrity of Antibody.

CFL2 Antibody in Immunohistochemistry (IHC (P))

CFL2 Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human skeletal muscle stained with CFL2 / NEM7 Mouse Monoclonal Antibody (CFL2/9963). Inset: PBS instead of primary antibody; secondary only negative control.

Summary

Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin, thereby regulating the rapid cycling of Actin assembly and disassembly essential for cellular viability. Cofilin is a low molecular weight protein that binds to filamentous (F) Actin by bridging two longitudinally associated Actin subunits changing the F-Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser-3 by factors such as opsonized zymosan. Lim kinase 1, a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerise F-Actin.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Species Reactivity
Human
Research Areas
Signal Transduction
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cytoplasm, Cytoskeleton, Nucleus matrix
Gene Name
CFL2
Immunogen
Recombinant fragment (around aa1-166) of human CFL2 protein (exact sequence is proprietary)
Alternate Names
cofilin-2, CFL 2 antibody; CFL2 antibody; COF2_HUMAN antibody; Cofilin 2 muscle antibody; Cofilin antibody; Cofilin muscle antibody; Cofilin muscle isoform antibody; Cofilin-2 antibody; Cofilin2 antibody; muscle isoform antibody; NEM 7 antibody; NEM7 antibody, NEM7

Database Links

Entrez Gene ID
1073
SwissProt
Q9Y281

Additional Information

Clone
CFL2/9963
Chromosome Location
14q13.1
Mol. Weight of Antigen
19-21kDa

Related Antibodies

View All CFL2 Antibodies

Key References

  • Nguyen MT, Min KH, Kim D, Park SY, Lee W. CFL2 is an essential mediator for myogenic differentiation in C2C12 myoblasts. Biochem Biophys Res Commun. 2020;533(4):710-716. doi:10.1016/j.bbrc.2020.11.016
  • Zhang L, Zhang W, Zuo Z, et al. Circ_0008673 regulates breast cancer malignancy by miR-153-3p/CFL2 axis. Arch Gynecol Obstet. 2022;305(1):223-232. doi:10.1007/s00404-021-06149-w
  • Fattori F, Fiorillo C, Rodolico C, et al. Expanding the histopathological spectrum of CFL2-related myopathies. Clin Genet. 2018;93(6):1234-1239. doi:10.1111/cge.13240

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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