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CD5 (Mantle Cell Lymphoma Marker) Antibody [CRIS-1]

Additional information

Catalog Number: 921-MSM4
Reactivity:

,

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
921-MSM4-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
921-MSM4-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
921-MSM4-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
CD5 (Mantle Cell Lymphoma Marker) Antibody

FCM staining of human PBMCs using CD5 Monoclonal Antibody (CRIS-1).

CD5 (Mantle Cell Lymphoma Marker) Antibody - Image 2

SDS-PAGE Analysis of Purified CD5 Monoclonal Antibody (CRIS-1). Confirmation of Integrity and Purity of Antibody.

  • Flow
  • Functional Studies
  • IF
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Functional Studies, Immunofluorescence
Species Reactivity
Human, Rhesus Monkey
Clone
CRIS-1
Isotype
IgG2a
Light Chain
Kappa
Cellular Localization
Cell membrane
Gene Name
CD5
Positive Control
293T, Ramos or MOLT-4 cells. Tonsil.
Immunogen
Stimulated human leukocytes
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • May act as a receptor in regulating T-cell proliferation.
Key References
  • Arrizabalaga P, Mirapeix E, Darnell A, Torras A, Revert L: Cellular immunity analysis using monoclonal antibodies in human glomerulonephritis. Nephron. 1989;53(1):41-9.
  • Alberola-Ila J, Places L, Cantrell DA, Vives J, Lozano F: Intracellular events involved in CD5-induced human T cell activation and proliferation. J Immunol. 1992;148(5):1287-93.
  • Leukocyte Typing III., McMichael A. J. et al. (Eds.), Oxford University Press (1987).
  • Guarne A, Bravo J, Calvo J, Lozano F, Vives J, Fita I: Conformation of the hypervariable region L3 without the key proline residue. Protein Sci. 1996;5(1):167-9.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
921
SwissProt
P06127
Chromosome Location
11q12.2
Mol. Weight of Antigen
~67kDa
Alternate Names
T-cell surface glycoprotein CD5, Lymphocyte antigen T1/Leu-1, CD5 antigen (p56 62), LEU1, Ly12, LyA, Lymphocyte antigen T1/Leu-1, Lymphocyte glycoprotein T1/Leu1, T-cell surface glycoprotein CD5

Summary

Recognizes a 67kDa transmembrane protein, which is identified as CD5 (HLDA I; WS Code T 29HLDA III; WS Code T 530). The CD5 antigen is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. Anti-CD5 is a pan T-cell marker that also reacts with a range of neoplastic B-cells, e.g. chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), mantle cell lymphoma, and a subset (~10%) of diffuse large B-cell lymphoma. CD5 aberrant expression is useful in making a diagnosis of mature T-cell neoplasms.

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