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CD100 (Semaphorin-4D) Antibody [A8]

Additional information

Catalog Number: 10507-MSM2
Reactivity:

, ,

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
10507-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
10507-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
10507-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
CD100 (Semaphorin-4D) Antibody

SDS-PAGE Analysis of Purified CD100 Mouse Monoclonal Antibody (A8). Confirmation of Purity and Integrity of Antibody.

  • Flow
  • Functional Studies
  • IF
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Flow Cytometry, Functional Studies, Immunofluorescence
Species Reactivity
Human, Monkey, Mouse
Clone
A8
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cell membrane
Gene Name
SEMA4D
Positive Control
Daudi, HUT-78, Kg1a, Raji, U937 and human lymphocytes. Human tonsils and lymph nodes.
Immunogen
PHA stimulated human peripheral blood lymphocytes
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703).
Key References
  • Hall K, et al. 1996. P. Natl. Acad. Sci. USA 93:11780.
  • Schlossman SL Bloumsell W Gilks et al. eds. 1995. Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press New York.
  • Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
  • Bougeret CIG Mansur H Dastot et al. 1992. Increased surface expression of a newly identified 150 kDa dimer early after human T lymphocyte activation. J. Immunol. 148:318.
  • Mizrahi S, et al. 2007. PLoS One. 2(9):e818.
  • Knapp WB Dorken EP. Rieber et al, eds. 1989. Leucocyte Typing IV: White Cell Differentiation Antigens. Oxford University Press New York.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
10507
SwissProt
Q92854
Chromosome Location
9q22.2
Mol. Weight of Antigen
50kDa (Monomer)
Alternate Names
Semaphorin-4D, A8, BB18, GR3, COLL4; Collapsin4; GR3; M sema G; MSEMA; SEMA4D; Semacl2; SemaH; SEMAJ; Semaphorin C like 2; Semaphorin H; Semaphorin J; Semaphorin-4D; Semcl2

Summary

Recognizes a homodimeric protein comprised of 50kDa subunits, identified as CD100. It is expressed on majority of haemopoietic cells (B, T, NK and myeloid cells) and is absent from bone marrow, erythrocytes, eosinophils and endothelial cells. Its expression is increased after PHA-activation. CD100 was shown to associate with different partner molecules in T cells such as CD45, a key molecule with protein tyrosine phosphatase activity involved in T-cell transduction, and a Serine kinase. It plays a role in homotypic cell adhesion and in T cell activation.

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