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BACH2 (Transcription Factor) Antibody [PCRP-BACH2-5B11]

In Stock
Catalog Number Formulation Size Price
60468-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
60468-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
60468-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells

Summary

Enables sequence-specific double-stranded DNA binding activity. Involved in primary adaptive immune response involving T cells and B cells. Located in cytosol and nucleoplasm. Implicated in immunodeficiency 60. Transcriptional regulator that acts as a repressor or activator. Binds to Maf recognition elements (MARE). Plays an important role in coordinating transcription activation and repression by MAFK. Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1. Positively regulates the nuclear import of actin. Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Research Areas
Isotype / Light Chain
IgG2a / Kappa
Cellular Localization
Nucleus
Gene Name
Positive Control
B-cell specific.
Immunogen
Recombinant fragment (around aa11-132) of human BACH2 protein
Alternate Names
Transcription regulator protein BACH2, BTB and CNC homolog 2, BTB and CNC homology 1; basic leucine zipper transcription factor 2

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
PCRP-BACH2-5B11
Chromosome Location
6q15
Mol. Weight of Antigen
92.54kDa

Functions

  • Transcriptional regulator that acts as a repressor or activator (By similarity). Binds to Maf recognition elements (MARE) (By similarity). Plays an important role in coordinating transcription activation and repression by MAFK (By similarity). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713).

Key References

  • Desouki MM., et al. Clin Med Res.2010 Jul;8(2):84-8.
  • Statement for PublicationAll investigators should include an acknowledgment in the publications the benefit from the use of this product. Suggested statement: PCRP-PAX5-1B1 was developed by JHU/CDI under Protein Capture Reagents Program of NICHD of the NIH.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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