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Alpha-1-Antitrypsin (SERPINA1) (Hepatocellular & Histiocytic Marker) Antibody [AAT/1379]

Additional information

Catalog Number: 5265-MSM2
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
5265-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
5265-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
5265-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Alpha-1-Antitrypsin (SERPINA1) (Hepatocellular & Histiocytic Marker) Antibody

Formalin-fixed, paraffin-embedded human Tonsil stained with Alpha-1-Antitrypsin Mouse Monoclonal Antibody (AAT/1379).

Alpha-1-Antitrypsin (SERPINA1) (Hepatocellular & Histiocytic Marker) Antibody - Image 2

SDS-PAGE Analysis of Purified Alpha-1-Antitrypsin Mouse Monoclonal Antibody (AAT/1379). Confirmation of Integrity and Purity of Antibody.

SERPINA1 Antibody in Western Blot (WB)

SERPINA1 Antibody in Western Blot (WB)

Western blot analysis of human Lung tissue lysate using SERPINA1 Mouse Monoclonal Antibody (AAT/1379).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
AAT/1379
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Endoplasmic reticulum, Extracellular matrix, Extracellular space, Secreted
Gene Name
SERPINA1
Positive Control
Hepatocellular Carcinoma or Histiocytoma., HepG2 cells. Tonsil, Lung
Immunogen
Recombinant human Alpha-1-Antitrypsin (AAT) protein fragment
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
  • Reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).
Key References
  • Atkinson, G.W., Ann Clin Lab Sci 3:345-352, 1973.Kyaw-Myint, T.O., et al., Clin Chem Acta 59:51-54, 1975.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
5265
SwissProt
P01009
Chromosome Location
14q32.1
Mol. Weight of Antigen
46kDa
Alternate Names
Alpha-1-antitrypsin, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1, A1AT; AAT; Alpha 1 antiproteinase Alpha 1-antitrypsin; Alpha-1 protease inhibitor; Alpha-1-antiproteinase; alpha1 proteinase inhibitor; Alpha1AT; Dom1; Serine (or cysteine) proteinase inhibitor clade A member 1; Serine protease inhibitor 1-1; Serine protease inhibitor A1a; Serpin A1a; Serpin peptidase inhibitor clade A member 1; Serpina1; Short peptide from AAT; SPAAT; Spi1-1

Summary

The immunohistochemical staining of AAT is useful in identification of benign and malignant hepatic tumors and yolk sac carcinomas. Positive staining for AAT is also used in detection of benign and malignant lesions of histiocytic nature. This antibody is may also useful tool in the screening of patients with cryptogenic cirrhosis or other forms of liver disease with fibrosis of uncertain origin.

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