Recombinant HSV I + HSV II (Herpes Simplex Virus I & II) Antibody [HSV/12630]

Summary

This recombinant rabbit monoclonal antibody cocktail is designed for the sensitive and specific detection of herpes simplex virus (HSV) by targeting two essential viral proteins: ICP8 from HSV-1 and glycoprotein D (gD) from HSV-1 and HSV-2. ICP8 is a single-stranded DNA-binding protein that plays a pivotal role in HSV-1 DNA replication, recombination, and repair, acting as a critical component of the viral replication machinery. It promotes homologous recombination, facilitates strand exchange, and interacts with multiple viral and host factors essential for viral genome processing. Glycoprotein D (gD) is a key envelope protein required for HSV attachment and entry into host cells, binding to specific cellular receptors and triggering membrane fusion. This interaction is essential for viral infectivity and determines host cell tropism, with gD mutations significantly altering viral entry efficiency. While both HSV-1 and HSV-2 utilize gD for cellular entry, HSV-2 is the predominant cause of genital herpes, a lifelong and incurable condition primarily transmitted through sexual contact. By simultaneously detecting ICP8 and gD, this antibody cocktail enables comprehensive HSV identification across serotypes, ensuring high sensitivity and specificity. The recombinant rabbit monoclonal format provides unmatched reproducibility and specificity, eliminating variability associated with traditional antibodies and making this cocktail an optimal choice for pathology and virology studies.