TGFB3 / PEIG-1 / RAI3 / RAIG1 / TIG1 Antibody [TGFB3/4801]

These antibodies are validated on HuProtâ„¢ Human Protein Microarrays containing over 21,000 full-length human proteins, including the specific target of interest. LEARN MORE

Additional information

Catalog Number: 7043-MSM1
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

Carrier-Free Available

In Stock
Catalog Number Formulation Size Price
7043-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
7043-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
7043-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
  • IHC

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Host
Mouse
Applications
Species Reactivity
Clone
TGFB3/4801
Isotype
IgG2
Light Chain
Kappa
Cellular Localization
Secreted.
Gene Name
Positive Control
heart or lung.|Human kidney
Immunogen
Recombinant fragment (around aa50-250) of human TGFB3 protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

Related Antibodies

Other Information

Functions
Key References
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
SwissProt
Chromosome Location
14q24.3
Mol. Weight of Antigen
13kDa
Alternate Names
Transforming growth factor beta-3 proprotein | Latency-associated peptide | Transforming growth factor beta-3, ARVD1; LDS5; prepro-transforming growth factor beta-3; RNHF; TGFB 3; Tgfb3; transforming growth factor beta 3

Summary

Transforming growth factor βs (TGFβs) were originally discovered due to their ability to promote anchorage-independent growth of rat NRK fibroblasts in the presence of TGFβ. TGFβ1, TGFβ2 and TGFβ3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. TGFβ3 mediates many intercellular interactions that occur during embryonic development, cell differentiation and epithelial homeostasis. TGFβ3 overexpresses in extramammary Paget s disease (EPD) and downregulates in Bowen s disease, indicating that its expression is a useful indicator of tumor activity. TGFβ3 levels strongly correlate with IGF-1 and osteocalcin levels in serum. Significant amounts of TGFβ3 circulation appear to be representative of TGFβ3 expression in bone and may in part be derived from bone. Glucocorticoids may block TGFβ production by modulating mRNA levels and c-Jun activity.

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