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NEUROG3 / Neurogenin 3 / NGN3 (Transcription Factor) Antibody [NGN3/1809]

Additional information

Catalog Number: 50674-MSM2
Host:

Reactivity:

Gene:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
50674-MSM2-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
50674-MSM2-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
50674-MSM2-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
NEUROG3 / Neurogenin 3 / NGN3 (Transcription Factor) Antibody

Formalin-fixed, paraffin-embedded human brain stained with NEUROG3 Mouse Monoclonal Antibody (NGN3/1809) Inset: PBS instead of primary antibody; secondary only negative control.

NEUROG3 / Neurogenin 3 / NGN3 (Transcription Factor) Antibody - Image 2

Formalin-fixed, paraffin-embedded human brain stained with NEUROG3 Mouse Monoclonal Antibody (NGN3/1809) HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

NEUROG3 / Neurogenin 3 / NGN3 (Transcription Factor) Antibody - Image 3

SDS-PAGE Analysis NEUROG3 Mouse Monoclonal Antibody (NGN3/1809). Confirmation of Purity and Integrity of Antibody.

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
NGN3/1809
Isotype
IgG2b
Light Chain
Kappa
Cellular Localization
Nucleus.
Gene Name
NEUROG3
Positive Control
colon|HeLa cells. Human fetal gut|liver or heart.
Immunogen
Recombinant fragment (around aa1-200) of human NEUROG3 protein (exact sequence is proprietary)
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity).
Key References
  • Jacquemin, P., et al. 2000. Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3. Mol. Cell. Biol. 20: 4445-4454.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
50674
SwissProt
Q9Y4Z2
Chromosome Location
10q22.1
Mol. Weight of Antigen
23.54kDa
Alternate Names
Neurogenin-3, Class A basic helix-loop-helix protein 7, Protein atonal homolog 5, ATH4B; Atoh5; bHLHa7; Class A basic helix-loop-helix protein 7; Math4B; NEUROG3; Neurogenin-3; Neurogenin3; NGN-3; ngn3; Protein atonal homolog 5

Summary

This antigen is a transcription factor that interacts with NKX2-2 to regulation transcription of NEUROD1. The neurogenin family of proteins belongs to the basic helix-loop-helix (bHLH) superfamily and consists of Neurogenin 1, Neurogenin 2 and Neurogenin 3 (also designated ngn3). bHLH members are transcriptional regulators that determine cell fate. Neurogenin 3 is expressed in discrete regions of developing neurons and in the embryonic pancreatic islets of Langerhans. HNF-6 (hepatocyte nuclear factor 6) acts as a positive regulator of Neurogenin 3 by binding to and stimulating the neurogenin gene promoter. Neurogenin 3 is involved in the initial differentiation of the four islets cell types, while a network of transcription factors, including Hlxb9, Isl1, NeuroD, Nkx-2.2, Nkx-6.4, Pax-4, Pax-6, PDX-1 and Mash1, are required for final differentiation. Neurogenin 3 acts upstream of NeuroD in a bHLH cascade. Neurogenin 3 activates the expression of NeuroD at the onset of islet cell differentiation through box sequences E1 and E3 in the NeuroD promoter.

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