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Recombinant Platelet endothelial cell adhesion molecule Antibody [rPECAM1/8827]

Additional information

Catalog Number: 5175-MSM47
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
5175-MSM47-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
5175-MSM47-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
5175-MSM47-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant Platelet endothelial cell adhesion molecule Antibody

Formalin-fixed, paraffin-embedded human uterus stained with CD31 Mouse Monoclonal Antibody (rPECAM1/8827). HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

Recombinant Platelet endothelial cell adhesion molecule Antibody - Image 2

SDS-PAGE Analysis of Purified CD31 Mouse Monoclonal Antibody (rPECAM1/8827). Confirmation of Purity and Integrity of Antibody.

PECAM1 Antibody in Western Blot (WB)

PECAM1 Antibody in Western Blot (WB)

Western Blot Analysis of Human Heart, human Kidney and Human Spleen tissue lysates using CD31 Recombinant Mouse Monoclonal Antibody (rРЕСАМ1/8827).

Recombinant Platelet endothelial cell adhesion molecule Antibody - Image 4
PECAM1 Antibody in Western Blot (WB)

PECAM1 Antibody in Western Blot (WB)

Western blot analysis of human heart, kidney and spleen tissue lysates using PECAM1 Recombinant Mouse Monoclonal Antibody (rPECAM1/8827).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
rPECAM1/8827
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cell junction, Cell membrane, Membrane raft
Gene Name
PECAM-1
Positive Control
Jurkat cells. Tonsil or Angiosarcoma.|THP-1, Heart, Kidney, Spleen.
Immunogen
Recombinant fragment (around aa625-738) of the human CD31 protein (exact sequence is proprietary)
Expression System
HEK293
Purification
Protein G
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:17580308, PubMed:19342684). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity)., Does not protect against apoptosis.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
5175
SwissProt
P16284
Chromosome Location
17q23.3
Mol. Weight of Antigen
82.52kDa
Alternate Names
Platelet endothelial cell adhesion molecule, CD31|CD31/EndoCAM|GPIIA'|PECA1|PECAM-1|endoCAM

Summary

CD31 (PECAM-1) is a transmembrane glycoprotein member of the immunoglobulin supergene family of adhesion molecules. CD31 is expressed by stem cells of the hematopoietic system and is primarily used to identify and concentrate these cells for experimental studies as well as for bone marrow transplantation. Anti-CD31 has shown to be highly specific and sensitive for vascular endothelial cells. Staining of nonvascular tumors (excluding hematopoietic neoplasms) is rare. CD31 MAb reacts with normal, benign, and malignant endothelial cells which make up blood vessel lining. The level of CD31 expression can help to determine the degree of tumor angiogenesis, and a high level of CD31 expression may imply a rapidly growing tumor and potentially a predictor of tumor recurrence.

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