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Recombinant Thymidylate Synthase (5-FU Resistance Marker) Antibody [rTYMS/1884]

Additional information

Catalog Number: 7298-MSM6
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
7298-MSM6-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
7298-MSM6-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
7298-MSM6-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant Thymidylate Synthase (5-FU Resistance Marker) Antibody

SDS-PAGE Analysis of Purified TYMS Recombinant Mouse Monoclonal Antibody (rTYMS/1884). Confirmation of Purity and Integrity of Antibody.

Recombinant Thymidylate Synthase (5-FU Resistance Marker) Antibody - Image 2

Flow Cytometric Analysis of PFA-fixed MOLT4 cells. TYMS Recombinant Mouse Monoclonal Antibody (rTYMS/1884) followed by goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).

Recombinant Thymidylate Synthase (5-FU Resistance Marker) Antibody - Image 3

Immunofluorescence Analysis of PFA fixed MOLT-4 cells labeling Thymidylate Synthase Recombinant Mouse Monoclonal (rTYMS/1884) followed by Goat anti-mouse IgG-CF488 (Green). Membrane is labeled with Phalloiden (Red).

Thymidylate Synthase Antibody in Western Blot (WB)

Thymidylate Synthase Antibody in Western Blot (WB)

Western Blot Analysis of HeLa and Jurkat cell lysates using Thymidylate Synthase Recombinant Mouse Monoclonal Antibody (rSOX2/1792).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
rTYMS/1884
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Cytoplasm, Mitochondrion, Mitochondrion inner membrane, Mitochondrion matrix, Nucleus
Gene Name
TYMS
Positive Control
MOLT-4 or Ramos cells. Testicular carcinomas. Brain.
Immunogen
Recombinant fragment (around aa60-174) of the human Thymidylate Synthase protein (exact sequence is proprietary)
Expression System
HEK293
Purification
Protein G
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
7298
SwissProt
P04818
Chromosome Location
18p11.32
Mol. Weight of Antigen
35.72kDa
Alternate Names
Thymidylate synthase, DKCD|HST422|TMS|TS

Summary

It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). It converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein has been reported to associate with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.

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