Learn about our comprehensive antibody validation methods to ensure monospecificity.  Antibody Validation>>

YKL-39 / Chitinase 3 Like 2 (CHI3L2) Antibody [YKL39/6370]

In Stock
Catalog Number Formulation Size Price
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day


The CHI3L2 protein, also known as chitinase-3-like protein 2, is a glycoprotein that belongs to the chitinase protein family. It is primarily associated with various biological processes, including inflammation, tissue remodeling, and immune responses. CHI3L2 is expressed in various tissues, such as the lungs, liver, and immune cells, suggesting its involvement in diverse physiological functions.

CHI3L2 has been implicated in modulating immune responses and inflammatory processes. It is often associated with conditions characterized by inflammation, such as autoimmune diseases and certain cancers. The protein’s precise mechanism of action is still under investigation, but it is believed to play a role in cell signaling and the regulation of cellular interactions within the immune system.

HI3L2/YKL-39 has been explored as a biomarker in cancer diagnosis:Elevated levels of CHI3L2 in the serum or tissues have been investigated as potential biomarkers for cancer detection and prognosis. Monitoring CHI3L2 levels may aid in cancer diagnosis and assessment of disease progression. Inflammatory joint diseases, such as rheumatoid arthritis, have shown increased CHI3L2 expression. Detection of CHI3L2 levels in synovial fluid or blood may have diagnostic value in rheumatoid arthritis. CHI3L2/YKl-39 has also been explored as a biomarker for cardiovascular diseases. Elevated levels in the blood may indicate vascular inflammation and provide insights into cardiovascular risk.

Product Properties & Targets

Antibody Type
Species Reactivity
Isotype / Light Chain
IgG2 / Kappa
Cellular Localization
Gene Name
Positive Control
Highest expression in chondrocytes, followed by synoviocytes, lung and heart. Not detected in spleen, pancreas, and liver. May also be expressed in developing brain and placenta.
Recombinant human fragment corresponding to YKL-39 protein
Alternate Names
chitinase 3 like 2, YKL39, CH3L2_HUMAN; CHI3L2; Chitinase-3-like protein 2; Chondrocyte protein 39; YKL 39; YKL-39; YKL39

Database Links

Entrez Gene ID

Additional Information

Chromosome Location
Mol. Weight of Antigen

Key References

  • Liu L, Yang Y, Duan H, He J, Sun L, Hu W, Zeng J. CHI3L2 Is a Novel Prognostic Biomarker and Correlated With Immune Infiltrates in Gliomas. Front Oncol. 2021 Apr 15;11:611038. doi: 10.3389/fonc.2021.611038. PMID: 33937022; PMCID: PMC8084183.

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.


This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.


There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.


There are no reviews yet.

Be the first to review “YKL-39 / Chitinase 3 Like 2 (CHI3L2) Antibody”

Your email address will not be published. Required fields are marked *


We hold Exclusive rights to 10,000 recombinant and hybridoma antibody products, available for Licensing or Collaboration.