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Transthyretin (Prealbumin) Antibody [TTR/4295]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
7276-MSM5-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
7276-MSM5-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
7276-MSM5-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml

Summary

Prealbumin, also designated transthyretin, is a major thyroid-hormone binding protein involved in transporting thyroxine from the bloodstream to the brain. Prealbumin is located in the cytoplasm and in the vesicles of developing rat brain cells, and is thought to be transported there from the cerebrospinal fluid via endocytosis. Sequence variants of this protein have been identified in amyloid fibrils from patients with familial amyloidotic polyneuropathy (FAP), the most common form of hereditary systemic amyloidosis. Although the biologically active form of Prealbumin is a tetramer, the amyloidogenic intermediate is thought to be a monomeric species. Prealbumin also binds to the retinol carrier protein RBP (retinol-binding protein).

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Isotype / Light Chain
IgG2b / Kappa
Cellular Localization
Cytoplasm, Secreted
Gene Name
TTR
Positive Control
Human liver.
Immunogen
Recombinant human full-length protein
Alternate Names
Transthyretin, ATTR, Prealbumin, TBPA, Transthyretin; PALB; HsT2651; prealbumin, amyloidosis type 1; ATTR; TBPA; CTS; CTS1; carpal tunnel syndrome 1; thyroxine-binding prealbumin; prealbumin; HEL111; TTR protein; Epididymis luminal protein 111; prealbumin thyroxine binding; senile systemic amyloidosis antibody

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
TTR/4295
Chromosome Location
18q12.1
Mol. Weight of Antigen
15kDa

Functions

  • Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.

Key References

  • Westermark, P., et al. 2014. Ups. J. Med. Sci. 119: 223-228.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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