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Recombinant PMEPA1 / TMEPAI (Tumor Suppressor Oncoprotein) Antibody [rPMEPA1/6422]

Additional information

Catalog Number: 56937-MSM12
Gene:

Host:

Reactivity:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
56937-MSM12-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
56937-MSM12-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
56937-MSM12-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Recombinant PMEPA1 / TMEPAI (Tumor Suppressor Oncoprotein) Antibody

Formalin-fixed, paraffin-embedded human colon carcinoma stained with PMEPA1 Recombinant Mouse Monoclonal (rPMEPA1/6422).

Recombinant PMEPA1 / TMEPAI (Tumor Suppressor Oncoprotein) Antibody - Image 2

Formalin-fixed, paraffin-embedded human prostate stained with PMEPA1 Recombinant Mouse Monoclonal (rPMEPA1/6422).

Recombinant PMEPA1 / TMEPAI (Tumor Suppressor Oncoprotein) Antibody - Image 3

SDS-PAGE Analysis of Purified PMEPA1 Recombinant Mouse Monoclonal (rPMEPA1/6422). Confirmation of Purity and Integrity of Antibody.

PMEPA1 / TMEPAI Antibody in Western Blot (WB)

PMEPA1 / TMEPAI Antibody in Western Blot (WB)

Western Blot Analysis of HeLa cell lysate using PMEPA1 / TMEPAI Recombinant Mouse Monoclonal Antibody (rРМЕРА1/6422).

  • IHC
  • WB
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB) 2-4ug/ml Western Blot Protocol

Product Properties

Antibody Type
Recombinant Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Clone
rPMEPA1/6422
Isotype
IgG1
Light Chain
Kappa
Cellular Localization
Early endosome membrane, Golgi apparatus membrane
Gene Name
PMEPA1
Positive Control
Human prostate, breast or renal cell carcinoma tissue (IHC). HeLa.
Immunogen
Recombinant full-length human PMEPA1 protein
Expression System
HEK293
Purification
Protein G
Storage & Stability
Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab produced in a mammalian-based expression system. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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VIEW ALL ANTIBODIES

Other Information

Functions
  • Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514).
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
56937
SwissProt
Q969W9
Chromosome Location
20q13.31
Mol. Weight of Antigen
31.61kDa
Alternate Names
Protein TMEPAI, STAG1|TMEPAI

Summary

PMEPA1 (prostate transmembrane protein, androgen induced 1 is a 287 amino acid single-pass membrane protein that contains WW-binding motifs and localizes to the cell membrane. Expressed at high levels in prostate, kidney and ovary, PMEPA1 interacts with NEDD4 and may play a role in regulating AR (androgen receptor) levels, specifically in prostate cells. Down regulation of PMEPA1 is observed in prostate tumors, suggesting that PMEPA1 may exhibit activity as a tumor suppressor. Overexpression of this protein may play a role in multiple types of cancer.

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