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PMS1 Antibody [PCRP-PMS1-2E11]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
5378-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
5378-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
5378-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Flow Cytometry (Flow)
1-2ug/million cells
Immunofluorescence (IF)
1-2ug/ml

Summary

The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.

Product Properties & Targets

Antibody Type
Host
Mouse
Species Reactivity
Research Areas
Isotype / Light Chain
IgG1 /
Cellular Localization
Nucleus
Gene Name
Positive Control
HeLa, U-251 MG or CACO-2 cells.
Immunogen
Recombinant full-length human PMS1 protein
Alternate Names
PMS1 protein homolog 1, DNA mismatch repair protein PMS1, DNA mismatch repair protein PMS1; HNPCC3; hPMS1; Human homolog of yeast mutL; PMS1 postmeiotic segregation increased 1 (S. cerevisiae); PMS1 protein homolog 1; PMSL1; Rhabdomyosarcoma antigen MU RMS 40.10B / 40.10E

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
PCRP-PMS1-2E11
Chromosome Location
2q32.2
Mol. Weight of Antigen
105.8kDa

Functions

  • Probably involved in the repair of mismatches in DNA.

Key References

  • Blackshaw S, et al. A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nature methods 15.5 (2018 May): 330-338.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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