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PAX6 (Stem Cell Marker) Antibody [PAX6/15998]

In Stock
Catalog Number Formulation Size Price
5080-MSM37-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
5080-MSM37-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
5080-MSM37-P1ABX
Purified Ab WITHOUT BSA or Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
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Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Acts as a transcriptional repressor of NFATC1-mediated gene expression (By similarity).

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Isotype / Light Chain
IgG /
Cellular Localization
Nucleus
Gene Name
PAX6
Positive Control
Expressed in lymphoblasts
Immunogen
Recombinant fragment (around aa 165-284) of human PAX6 protein
Alternate Names
Paired box protein Pax-6, AN|AN1|AN2|ASGD5|D11S812E|FVH1|MGDA|WAGR

Database Links

Entrez Gene ID
5080
SwissProt
P26367

Additional Information

Clone
PAX6/15998
Chromosome Location
11p13
Mol. Weight of Antigen
46.68kDa
Purification
Protein A

Related Antibodies

View All PAX6 Antibodies

Functions

  • Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Acts as a transcriptional repressor of NFATC1-mediated gene expression (By similarity).

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
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