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MX1 / MX dynamin like GTPase 1 Antibody [MX1/7530]

In Stock
Catalog Number Formulation Size Price
4599-MSM5-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
4599-MSM5-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
4599-MSM5-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day
SDS-PAGE Analysis Purified MX1 Mouse Monoclonal Antibody (MX1/7530). Confirmation of Purity and Integrity of Antibody.

SDS-PAGE Analysis Purified MX1 Mouse Monoclonal Antibody (MX1/7530). Confirmation of Purity and Integrity of Antibody.

IHC analysis of formalin-fixed, paraffin-embedded human ovarian cancer. MX1 Mouse Monoclonal Antibody (MX1/7530). Inset: PBS instead of primary antibody; secondary only negative control.

IHC analysis of formalin-fixed, paraffin-embedded human ovarian cancer. MX1 Mouse Monoclonal Antibody (MX1/7530). Inset: PBS instead of primary antibody; secondary only negative control.

IHC analysis of formalin-fixed, paraffin-embedded human kidney. MX1 Mouse Monoclonal Antibody (MX1/7530). Inset: PBS instead of primary antibody; secondary only negative control.

IHC analysis of formalin-fixed, paraffin-embedded human kidney. MX1 Mouse Monoclonal Antibody (MX1/7530). Inset: PBS instead of primary antibody; secondary only negative control.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

The Dynamin family of microtubule-associated proteins function as GTPases that are involved in microtubule bundling and endocytosis. In mice, Mx2 (myxovirus resistance protein 2) and Mx1 (myxovirus resistance protein 1) are members of the Dynamin family that are involved in the immune response to viral infections. Localized to the cytoplasm, Mx2 contains one GED domain and is expressed in response to viral infection or treatment by IFN-a/IFN-b. Once expression is induced, Mx2 accumulates in the cytoplasm and inhibits the replication of vesicular stomatitis virus (VSV), thereby conferring resistance to VSV infection. Unlike Mx2, Mx1 is localized to the nucleus where, upon induction by IFN-a/IFN-b, it provides selective resistance to infection by the highly lethal H5N1 influenza virus. In humans, MxA and MxB function in a similar manner to Mx1 and Mx2, conferring resistance to specific target viruses. Mx3 is a rat-specific member of the myxovirus resistance protein family.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Research Areas
Immunology, Cytokine Signaling, Nuclear Marker
Isotype / Light Chain
IgG2 / Kappa
Cellular Localization
Cytoplasm.
Gene Name
MX1
Positive Control
breast cancer or colon cancer tissues.|Human spleen|Tonsil
Immunogen
Recombinant fragment (around aa400-592) of human MX1 protein (exact sequence is proprietary)
Alternate Names
Interferon-induced GTP-binding protein Mx1 | Interferon-induced GTP-binding protein Mx1, N-terminally processed, Interferon-induced protein p78, Interferon-regulated resistance GTP-binding protein MxA, Myxoma resistance protein 1, Myxovirus resistance protein 1, Human interferon regulated resistance GTP binding protein MXA; IFI78K; Interferon induced GTP binding protein Mx1; Interferon inducible protein p78; Interferon regulated resistance GTP binding protein MxA; MxA; Myxoma resistance protein 1; Myxovirus (influenza virus) resistance 1 interferon inducible; N-terminally processed

Database Links

Entrez Gene ID
4599
SwissProt
P20591

Additional Information

Clone
MX1/7530
Chromosome Location
21q22.3
Mol. Weight of Antigen
72kDa

Related Antibodies

View All MX1 Antibodies

Functions

  • Interferon-induced dynamin-like GTPase with antiviral activity against a wide range of RNA viruses and some DNA viruses. Its target viruses include negative-stranded RNA viruses and HBV through binding and inactivation of their ribonucleocapsid. May also antagonize reoviridae and asfarviridae replication. Inhibits thogoto virus (THOV) replication by preventing the nuclear import of viral nucleocapsids. Inhibits La Crosse virus (LACV) replication by sequestering viral nucleoprotein in perinuclear complexes, preventing genome amplification, budding, and egress. Inhibits influenza A virus (IAV) replication by decreasing or delaying NP synthesis and by blocking endocytic traffic of incoming virus particles. Enhances ER stress-mediated cell death after influenza virus infection. May regulate the calcium channel activity of TRPCs.

Key References

  • Hug, H., et al. 1988. Organization of the murine Mx gene and characterization of its interferon- and virus-inducible promoter. Mol. Cell. Biol. 8: 3065-3079.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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