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Interferon alpha Antibody [IFNA/6689]

In Stock
Catalog Number Formulation Size Price
3439-MSM7-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
3439-MSM7-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
3439-MSM7-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day
Formalin-fixed, paraffin-embedded human spleen stained with Interferon alpha 1 Mouse Monoclonal Antibody (IFNA/6689) at 2ug/ml. Inset: PBS instead of primary antibody; secondary only negative control

Formalin-fixed, paraffin-embedded human spleen stained with Interferon alpha 1 Mouse Monoclonal Antibody (IFNA/6689) at 2ug/ml. Inset: PBS instead of primary antibody; secondary only negative control

IHC analysis of formalin-fixed, paraffin-embedded human tonsil. Stained using IFNA/6689 at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

IHC analysis of formalin-fixed, paraffin-embedded human tonsil. Stained using IFNA/6689 at 2ug/ml in PBS for 30min RT. HIER: Tris/EDTA, pH9.0, 45min. 2°C: HRP-polymer, 30min. DAB, 5min.

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml
Western Blot Protocol

Summary

This MAb is specific for human interferon alpha 1 and does not cross react with human interferon alpha 2. Interferons are widely used therapeutic agents because of their anti-tumor and anti-viral effects and because of their modulatory effects on the immune system. These cytokines produce their effects by binding to the Type 1 Interferon- & Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is influenced by phosphorylation of Serine 535 and 539 in the IFNAR1.Produced by macrophages, IFN-alphas have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Research Areas
Cardiovascular, Immunology, Cytokine Signaling, Infectious Disease
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Secreted
Gene Name
IFNA1, IFNA13
Positive Control
Stimulated human peripheral blood mononuclear cells
Immunogen
Recombinant human IFNA1 protein
Alternate Names
Interferon alpha-1/13, Interferon alpha-D, IFN alpha; IFN alpha 1/13; IFN alpha 1b; Interferon alpha 13 (IFNA13); Interferon alpha leukocyte (IFL); Interferon alpha-1/13 (IFN-alpha-1/13); Interferon alpha-D (IFN alphaD); Interferon alpha1 (IFNA1); LeIF D

Database Links

Entrez Gene ID
3439
SwissProt
P01562

Additional Information

Clone
IFNA/6689
Chromosome Location
9q21.3
Mol. Weight of Antigen
16-27kDa

Related Antibodies

Functions

  • Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

Key References

  • Pestka S et al. Interferons and their actions. Annu Rev Biochem 1987, 56:727-777.
  • Sen GC et al. The interferon system. A bird's eye view of its biochemistry. J Biol Chem 1992, 267(8):5017-5020.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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