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Insulinoma Associated 2 / INSM2 Antibody [INSM2/4291]

In Stock
HuProt Validated
Catalog Number Formulation Size Price
84684-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
84684-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
84684-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

IA-6, also known as insulinoma-associated 2 or INSM2, is related to IA-1 (INSM1), a zinc-finger factor that is expressed in the developing nervous system. While the exact function of IA-6 is not known, other related insulinoma-associated proteins such as IA-2 are major autoantigens in type 1 diabetes. The homology exhibited by IA-6 to IA-1 has led to speculation that IA-6 may also play a role in the regulation of gene transcription. INSM2 may function as a growth suppressor or tumor suppressor in liver cells and in certain neurons.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG1 / Kappa
Cellular Localization
Cytoplasm, Nucleus
Gene Name
Positive Control
Human pancreas tissue.
Immunogen
Recombinant fragment of human INSM2 protein (around aa 432-540) (exact sequence is proprietary)
Alternate Names
Insulinoma-associated protein 2, Zinc finger protein IA-6, IA1; Insulinoma associated protein 2 (IA2); Zinc finger protein IA6

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
INSM2/4291
Chromosome Location
14q13.2
Mol. Weight of Antigen
58kDa

Functions

  • May function as a growth suppressor or tumor suppressor in liver cells and in certain neurons.

Key References

  • Li, Q., et al. 1997. Molecular characterization of the promoter region of a neuroendocrine tumor marker, IA-1. Biochem. Biophys. Res. Commun. 236:776-781.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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