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HK1 / Hexokinase 1 Antibody [HK1/9509]

In Stock
Catalog Number Formulation Size Price
3098-MSM6-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
3098-MSM6-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
3098-MSM6-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day
HK1 Antibody in SDS-PAGE

HK1 Antibody in SDS-PAGE

SDS-PAGE Analysis Purified HK1 Mouse Monoclonal Antibody (HK1/9509). Confirmation of Purity and Integrity of Antibody.

Hexokinase 1 Antibody in Immunohistochemistry (IHC (P))

Hexokinase 1 Antibody in Immunohistochemistry (IHC (P))

Formalin-fixed, paraffin-embedded human brain stained with Hexokinase 1 Mouse Monoclonal Antibody (HK1/9509). Inset: PBS instead of primary antibody; secondary only negative control.

HK1 Antibody in Western Blot (WB)

HK1 Antibody in Western Blot (WB)

Western blot analysis of human brain tissue lysate using HK1 Mouse Monoclonal Antibody (HK1/9509).

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
IHC Protocol
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes
Western Blot (WB)
2-4ug/ml
Western Blot Protocol

Summary

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in several transcript variants which encode different isoforms, some of which are tissue-specific.

Product Properties & Targets

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry, Western Blot
Species Reactivity
Human
Research Areas
Cardiovascular
Isotype / Light Chain
IgG2b / Kappa
Cellular Localization
Secreted
Gene Name
HK1
Positive Control
Human Brain
Immunogen
Recombinant fragment (around aa1-200) of human HK1 protein (exact sequence is proprietary)
Alternate Names
hexokinase 1, HK; HKD; HKI; HXK1; NMSR; RP79; HMSNR; HK1-ta, Neuropathy, hereditary motor and sensory, Russe type

Database Links

Entrez Gene ID
3098
SwissProt
P19367

Additional Information

Clone
HK1/9509
Chromosome Location
10q22.1
Mol. Weight of Antigen
102kDa

Related Antibodies

View All HK1 Antibodies

Key References

  • He X, Lin X, Cai M, et al. Overexpression of Hexokinase 1 as a poor prognosticator in human colorectal cancer. Tumour Biol. 2016;37(3):3887-3895. doi:10.1007/s13277-015-4255-8
  • Schindler A, Foley E. Hexokinase 1 blocks apoptotic signals at the mitochondria. Cell Signal. 2013;25(12):2685-2692. doi:10.1016/j.cellsig.2013.08.035

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C.Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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