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GITR / Tnfrsf18 (Mouse) Antibody [DTA-1]

In Stock
Catalog Number Formulation Size Price
MS21936-RTM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
MS21936-RTM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
MS21936-RTM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day
SDS-PAGE Analysis of Purified GITR Mouse Monoclonal Antibody (DTA-1). Confirmation of Purity and Integrity of Antibody.

SDS-PAGE Analysis of Purified GITR Mouse Monoclonal Antibody (DTA-1). Confirmation of Purity and Integrity of Antibody.

Applications & Dilutions

Applications Tested Dillution Protocol
Flow Cytometry (Flow)
1-2ug/million cells
Flow Cytometry Protocol
Immunofluorescence (IF)
1-3ug/ml

Summary

GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+CD4+Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-B activation, and abrogate the inhibitory function ofCD25+CD4+Tregs. In vivoactivation of GITR causes development of autoimmune diseases and restores the suppressed immune response.

Product Properties & Targets

Antibody Type
Rat Monoclonals
Host
Rat
Applications
Flow Cytometry, Immunofluorescence
Species Reactivity
Mouse
Isotype / Light Chain
IgG2b / Lambda
Cellular Localization
Cell membrane, Secreted
Gene Name
Tnfrsf18
Positive Control
CD25+CD4+Tregs.
Immunogen
Mouse CD25+ CD4+ T cells
Alternate Names
Tumor necrosis factor receptor superfamily member 18, Glucocorticoid-induced TNFR-related protein, Activation-inducible TNF-related ligand; AITRL; GITRL; Glucocorticoid induced TNFR related protein ligand; Glucocorticoid-induced TNF-related ligand; hGITRL; TL6; TNFSF18; Tumor necrosis factor (ligand) superfamily member 18

Database Links

Entrez Gene ID
21936
SwissProt
O35714

Additional Information

Clone
DTA-1
Chromosome Location
4; 4E (Mouse)
Mol. Weight of Antigen
66-70kDa (Homodimer)

Related Antibodies

View All Tnfrsf18 Antibodies

Functions

  • Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway (By similarity).

Key References

  • Stephens GL, et al. 2004. J. Immunol. 173:5008.
  • Tone M, et al. 2003. Proc. Natl. Acad. Sci. USA 100:15059.

PubMed Links

Storage & Stability

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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