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GITR / Tnfrsf18 (Mouse) Antibody [DTA-1]

Additional information

Catalog Number: MS21936-RTM1
Reactivity:

Gene:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
MS21936-RTM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
MS21936-RTM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
MS21936-RTM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
GITR / Tnfrsf18 (Mouse) Antibody

SDS-PAGE Analysis of Purified GITR Mouse Monoclonal Antibody (DTA-1). Confirmation of Purity and Integrity of Antibody.

  • Flow
  • IF
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol
Flow Cytometry (Flow) 1-2ug/million cells Flow Cytometry Protocol
Immunofluorescence (IF) 1-3ug/ml

Product Properties

Antibody Type
Rat Monoclonals
Host
Rat
Applications
Flow Cytometry, Immunofluorescence
Species Reactivity
Mouse
Clone
DTA-1
Isotype
IgG2b
Light Chain
Lambda
Cellular Localization
Cell membrane, Secreted
Gene Name
Tnfrsf18
Positive Control
CD25+CD4+Tregs.
Immunogen
Mouse CD25+ CD4+ T cells
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway (By similarity).
Key References
  • Stephens GL, et al. 2004. J. Immunol. 173:5008.
  • Tone M, et al. 2003. Proc. Natl. Acad. Sci. USA 100:15059.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
21936
SwissProt
O35714
Chromosome Location
4; 4E (Mouse)
Mol. Weight of Antigen
66-70kDa (Homodimer)
Alternate Names
Tumor necrosis factor receptor superfamily member 18, Glucocorticoid-induced TNFR-related protein, Activation-inducible TNF-related ligand; AITRL; GITRL; Glucocorticoid induced TNFR related protein ligand; Glucocorticoid-induced TNF-related ligand; hGITRL; TL6; TNFSF18; Tumor necrosis factor (ligand) superfamily member 18

Summary

GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+CD4+Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-B activation, and abrogate the inhibitory function ofCD25+CD4+Tregs. In vivoactivation of GITR causes development of autoimmune diseases and restores the suppressed immune response.

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