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Follistatin / Activin Binding Protein Antibody [FST/4281]

In Stock
Catalog Number Formulation Size Price
10468-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$229.00
10468-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$519.00
10468-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$519.00
Flat Rate Domestic: $60 | Orders outside the US - Contact Us for Order Information | Ships next business day

Applications & Dilutions

Applications Tested Dillution Protocol Note
Immunohistochemistry (IHC)
1-2ug/ml
30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Summary

Follistatin is a single-chain glycosylated protein that inhibits follicle stimulating hormone (FSH) release. Alternative splicing of Follistatin mRNA yields two isoforms, FS315 and FS288. FS288 is the main cell-surface form and binds to surface heparin sulphate proteoglycans. FST/4281 is a clone raised against recombinant Fst 288, and is used in combination, commonly as the capture, with antibody FST/4282 in a two site ELISA for the detection of Follistatin.

Product Properties & Targets

Antibody Type
Host
Mouse
Applications
Species Reactivity
Isotype / Light Chain
IgG1 /
Cellular Localization
Secreted
Gene Name
FST
Positive Control
Human testis or ovary.
Immunogen
Raised to human Follistatin (Fst) 288 and recognizes both human Fst 288 and 315
Alternate Names
Follistatin, Activin-binding protein, Follistatin, FS, FST, Active-binding protein

Database Links

Entrez Gene ID
SwissProt

Additional Information

Clone
FST/4281
Chromosome Location
5q11.2
Mol. Weight of Antigen
37kDa

Functions

  • Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH).

Key References

  • Evans, L. (1998). Journal of Endocrinology 156.2; 275-82.

Storage & Stability

Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Limitations

This antibody is available for research use only and is not approved for use in diagnosis.

Supplied as

200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Warranty

There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.

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