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Cytokeratin 16 (KRT16) (Suprabasal Keratinocyte Marker) Antibody [LL025]

Additional information

Catalog Number: 3868-MSM1
Gene:

Reactivity:

Host:

In Stock

Trial Size Available

Carrier-Free Available

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In Stock
Catalog Number Formulation Size Price
3868-MSM1-P0
Purified Ab with BSA and Azide at 200ug/ml
20ug
$259.00
3868-MSM1-P1
Purified Ab with BSA and Azide at 200ug/ml
100ug
$559.00
3868-MSM1-P1ABX
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
100ug
$559.00
Flat Rate Domestic: $95 | Orders outside the US - Contact Us for Order Information | Ships next business day
Cytokeratin 16 (KRT16) (Suprabasal Keratinocyte Marker) Antibody

Formalin-fixed, paraffin-embedded human Tonsil stained with Cytokeratin 16 Mouse Monoclonal Antibody (LL025).

Cytokeratin 16 (KRT16) (Suprabasal Keratinocyte Marker) Antibody - Image 2

SDS-PAGE Analysis of Purified Cytokeratin 16 Mouse Monoclonal Antibody (LL025). Confirmation of Purity and Integrity of Antibody.

  • IHC
  • Documents
  • Applications & Dilutions
  • Product Properties
  • other information

Documents

Document Name
Datasheet Download Here
Material Safety Data Sheet Download Here

Applications & Dilutions

Applications Tested Dilutions Protocol Note
Immunohistochemistry (IHC) 1-2ug/ml IHC Protocol 30 min at RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes

Product Properties

Antibody Type
Mouse Monoclonals
Host
Mouse
Applications
Immunohistochemistry
Species Reactivity
Human
Clone
LL025
Isotype
IgG1
Light Chain
Kappa
Gene Name
KRT16
Positive Control
HeLa cells. Tonsil, Skin. Bladder or Cervix.
Immunogen
A synthetic peptide from the C-terminal of human Cytokeratin 16
Storage & Stability
Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Supplied as
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Limitations
This antibody is available for research use only and is not approved for use in diagnosis.

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Other Information

Functions
  • Epidermis-specific type I keratin that plays a key role in skin. Acts as a regulator of innate immunity in response to skin barrier breach: required for some inflammatory checkpoint for the skin barrier maintenance.
Key References
  • Markey et al. 1992. Br J Dermatol. 126(2):154-60.
  • Wetzels et al. 1991. Am J Pathol. 138(3):751-63.
  • Porter et al. 2000. Lab Invest. 80(11):1701-10.
PubMed Links
Warranty
There are no warranties, expressed or implied, which extend beyond this description. Company is not liable for any personal injury or economic loss resulting from this product.
Entrez Gene ID
3868
SwissProt
P08779
Chromosome Location
17q21.2
Mol. Weight of Antigen
48kDa
Alternate Names
Keratin, type I cytoskeletal 16, Cytokeratin-16, Keratin-16, CK16; Cytokeratin-16; Focal non epidermolytic palmoplantar keratoderma (FNEPPK / NEPPK); K1CP; Keratin Type I Cytoskeletal 16; Keratin-16; KRT16A

Summary

Cytokeratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I Cytokeratins (Cytokeratins 9 to 23) and one type II Cytokeratins (keratins 1 to 8). The cytokeratin proteins play a critical role in differentiation, as well as tissue specialization and function, to maintain the overall structural integrity of epithelial cells. Cytokeratins are also useful markers in identifying the origin of metastatic tumors. Cytokeratin 16 is expressed in benign stratified squamous epithelium and squamous cell carcinoma of the head and neck, as well as luminal cells of mammary gland and sweat ducts. It is absent in non-invasive breast carcinomas and normal breast tissue.

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